Results 101 to 110 of about 2,292,684 (349)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The design and analysis of single flank transmission error tester for loaded gears [PDF]
To strengthen the understanding of gear transmission error and to verify mathematical models which predict them, a test stand that will measure the transmission error of gear pairs under design loads has been investigated.
Bassett, Duane E., Houser, Donald R.
core +1 more source
An analysis of cross-coupling of a multicomponent jet engine test stand using finite element modeling techniques [PDF]
A two axis thrust measuring system was analyzed by using a finite a element computer program to determine the sensitivities of the thrust vectoring nozzle system to misalignment of the load cells and applied loads, and the stiffness of the structural ...
Schweikhard, W. G., Singnoi, W. N.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Study on the hydrothermal effect in ice materials under the polar glacier runway dynamic load
Case Studies in Construction MaterialsThe problem of ice transportation during the polar scientific expedition is very important. In order to provide a research basis for the glacier runway in the polar region, this paper approximates the load generated by the aircraft running on the glacier
Zhiyuan Wang +5 more
doaj +1 more source
Polish Maritime Research, 2015 The dynamic strength and accumulated plastic strain are two important parameters for evaluating the dynamic response of soil. As a special clay, the remolded red clay is often used as the high speed railway subgrade filling, but studies on its dynamic ...
Li Jian, Chen Shanxiong, Jiang Lingfa
doaj +1 more source
Experimental and analytical determination of characteristics affecting light aircraft landing-gear dynamics [PDF]
An experimental and analytical investigation was conducted to determine which characteristics of a light aircraft landing gear influence gear dynamic behavior significantly. The investigation focused particularly on possible modification for load control.
Fasanella, E. L. +2 more
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Testing on Dynamic Load of 200K Wire Rope Type Riser Tensioner
Shiyou jixie, 2017 In order to address the difficult of offshore drilling riser tensioner testing and to verify the reliability of domestic riser tensioner, the testing of riser tensioner has been carried out. Analyses on the speed and tension force of the wire rope of the
Zhou Tianming +6 more
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