Results 121 to 130 of about 2,292,684 (349)

Development and correlation: Viking Orbiter analytical dynamic model with modal test [PDF]

open access: yes
The Viking Orbiter (VO) experience in the achievement of a mathematical model is described along with the following project activities: (1) the generation of the overall plan for load analysis, an analytical dynamic model, and development tests; (2) the ...
Chen, J. C., Garba, J. A., Wada, B. K.
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

A Parallel Mesh-Adaptive Framework for Hyperbolic Conservation Laws

open access: yes, 2006
We report on the development of a computational framework for the parallel, mesh-adaptive solution of systems of hyperbolic conservation laws like the time-dependent Euler equations in compressible gas dynamics or Magneto-Hydrodynamics (MHD) and similar ...
Berger   +23 more
core   +1 more source

Conversion between static and dynamic load bearing capacity moduli and introduction of dynamic target values

open access: yes, 2008
Two types of Light Falling Weight Deflectometers (LFWD) are in use in Hungary: the German device (Zorn, HMP and Wemex) and the new B \rm & C small-plate device, which was developed by Andreas Ltd. Both devices are able to measure the dynamic load bearing
Zoltán Tompai
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

New Design Criteria for Long, Large-Diameter Bored Piles in Near-Shore Interbedded Geomaterials: Insights from Static and Dynamic Test Analysis

open access: yesBuildings
This paper presents an analysis of long, large-diameter bored piles’ behavior under static and dynamic load tests for a megaproject located in El Alamein, on the northern shoreline of Egypt.
Nagwa Elsakhawy   +3 more
doaj   +1 more source

Development of procedures for calculating stiffness and damping properties of elastomers in engineering applications. Part 4: Testing of elastomers under a rotating load [PDF]

open access: yes
A test rig designed to measure stiffness and damping of elastomer cartridges under a rotating load excitation is described. The test rig employs rotating unbalance in a rotor which runs to 60,000 RPM as the excitation mechanism.
Darlow, M. S., Smalley, A. J.
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The dynamic analysis of piping systems using pseudo-dynamic techniques [PDF]

open access: yes, 2001
This paper describes an application of pseudo-dynamic techniques to the dynamic analysis of piping structures. Essentially it consists in coupling a direct time integration algorithm, such as the Newmark method, to an experimental step.
Carneiro, J.O.   +4 more
core  

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