Results 61 to 70 of about 992,444 (308)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Experimental study on mechanical response of anchored fractured coal under cyclic dynamic loading

open access: yesMeikuang Anquan
In order to understand the mechanical response and failure characteristics of anchored fractured coal body under cyclic dynamic load, the dynamic load impact test of anchored fractured coal under cyclic impact dynamic load was carried out by using the ...
Zhen’an LI, Zhuang LI
doaj   +1 more source

In Situ Test Study of Characteristics of Coal Mining Dynamic Load

open access: yesShock and Vibration, 2015
Combination of coal mining dynamic load and high static stress can easily induce such dynamic disasters as rock burst, coal and gas outburst, roof fall, and water inrush. In order to obtain the characteristic parameters of mining dynamic load and dynamic
Jiang He   +4 more
doaj   +1 more source

Fault location in power distribution systems considering a dynamic load model

open access: yesIngeniería e Investigación, 2015
In the electrical power systems, load is one of the most difficult elements to be represented by an adequate mathematical model due to its complex composition and dynamic and non-deterministic behavior.
Harold Andres Cifuentes Chaves   +2 more
doaj   +1 more source

DYNAMIC OF PRESSURE-DEFORMATION CURVE IN UNIAXIAL COMPRESSION TEST IN DIFFERENT LOAD TIMES [PDF]

open access: yesEngenharia Agrícola, 2017
: The loading application time by machinery tires and agricultural tires is one of the factors of soil compaction. We evaluated the effect of loading reduction time in uniaxial compression test, in laboratory, in some physical and mechanical parameters ...
Michael Mazurana   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Study on the Impact Coefficient of Tied Arch Bridge Shock Effect Based on Vehicle-Bridge Coupling

open access: yesApplied Sciences
In order to study the impact on the shock effect when a high-speed train passes over a concrete-filled steel tube (CFST) tied-arch bridge, a dynamic load test was carried out in the background of the Qinjiang River Bridge in Qinzhou, Guangxi Province, to
Yipu Peng   +4 more
doaj   +1 more source

Dynamic Modeling of Cascading Failure in Power Systems

open access: yes, 2015
The modeling of cascading failure in power systems is difficult because of the many different mechanisms involved; no single model captures all of these mechanisms.
Cotilla-Sanchez, Eduardo   +3 more
core   +1 more source

Performance of bolted steel-beam to CFST-column joints using stiffened angles in column-removal scenario [PDF]

open access: yes, 2019
This paper presents three experimental investigations on the performance of steel-beam to CFST-column joints using stiffened angle, long bolts and fin plate under a middle column removal scenario. Three specimens were designed and tested.
Fu, F., Gao, S., Guo, L., Xu, M.
core   +1 more source

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