Results 61 to 70 of about 2,292,684 (349)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Jixie chuandong, 2021 Based on the lumped mass method， bending and torsion coupled dynamics model of the concentric face gear transmission system is established. The calculation method of floating quantity of input pinion is studied， the system dynamic equation is modified ...
Laiyang Shan +2 more
doaj
Experimental verification of frequency effects in tilting pad journal bearing dynamic coefficients
Nihon Kikai Gakkai ronbunshu, 2021 In this paper, vibrational frequency effect in dynamic coefficients of tilting pad journal bearing is verified experimentally. Tilting pad journal bearings (TPJB) is applied in various turbomachinery. Accurate evaluation of the bearing characteristics of
Nobuhiro NAGATA +3 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
InfrastructuresIn this paper, joint precast piles with a cross-section of 400 × 400 mm and a pin-joined connection were considered, and their interaction with the soil of Western Kazakhstan has been analyzed.
Abdulla Omarov +6 more
doaj +1 more source
Simplified Algorithm for Dynamic Demand Response in Smart Homes Under Smart Grid Environment
, 2019 Under Smart Grid environment, the consumers may respond to incentive--based smart energy tariffs for a particular consumption pattern. Demand Response (DR) is a portfolio of signaling schemes from the utility to the consumers for load shifting/shedding ...
Namboodiri, Aryesh +2 more
core +1 more source
Performance of bolted steel-beam to CFST-column joints using stiffened angles in column-removal scenario [PDF]
, 2019 This paper presents three experimental investigations on the performance of steel-beam to CFST-column joints using stiffened angle, long bolts and fin plate under a middle column removal scenario. Three specimens were designed and tested.
Fu, F., Gao, S., Guo, L., Xu, M.
core +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source