Results 71 to 80 of about 992,444 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Experimental dynamic analysis of the footbridge across Jizera River in Mladá Boleslav

Acta Polytechnica CTU Proceedings
The text of this submitted paper is devoted to the experimental dynamic analysis of the newly designed footbridge across the Jizera River in Mladá Boleslav.
Miroslav Čáp, Vladimír Šána, Michal Polák, Tomáš Plachý   +3 more
doaj   +1 more source

Development of measurement-based load models for the dynamic simulation of distribution grids [PDF]

, 2017
The advent of new types of loads, such as power electronics and the increased penetration of low-inertia motors in the existing distribution grids alter the dynamic behavior of conventional power systems. Therefore, more accurate dynamic, aggregate, load
Burt, Graeme M., Chrysochos, Andreas I., Guillo-Sansano, Efren, Kontis, Eleftherios O., Papadopoulos, Theofilos A., Papagiannis, Grigoris K., Syed, Mazheruddin H.   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Dynamic Response Analysis of Overpass Ramp Based on Grey System Theory Model

Applied Sciences
An interchange is a pivotal traffic facility that connects highways and controls access. It is necessary to study their dynamic response characteristics to analyze the operational safety of ramp bridges on interchanges.
Yongcheng Ji, Guangwen Liao, Wenyuan Xu
doaj   +1 more source

Using Support Vector Machine for Prediction Dynamic Voltage Collapse in an Actual Power System [PDF]

, 2008
—This paper presents dynamic voltage collapse prediction on an actual power system using support vector machines. Dynamic voltage collapse prediction is first determined based on the PTSI calculated from information in dynamic simulation
Hussain, Aini, Mohamed , Azah, Nizam , Muhammad   +2 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Enhancing Quality Management of PHC Piles through Improved Driving Formulas: A Comprehensive Review and Analysis

Applied Sciences
In construction projects, conducting dynamic load tests on all piles proves impractical. Selective testing estimates bearing capacity, while the remaining piles rely on penetration depth for management.
Gunwoong Kim, Seunghwan Seo, Juhyong Kim, Changho Choi, Moonkyung Chung   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Determination of the Correlation Dependence Between Static and Dynamic Modulus of Deformation of the Granular Sub-Ballast Layers

Civil and Environmental Engineering
Technological procedures related to the possession of tracks are often under heavy time constraints. Therefore, the attempts to apply dynamic load tests in the process of diagnostics of implemented construction works on modernised sections of railway ...
Ižvolt Libor, Dobeš Peter, Mečár Martin   +2 more
doaj   +1 more source