Results 81 to 90 of about 2,292,684 (349)

Dynamic Modeling of Cascading Failure in Power Systems

, 2015
The modeling of cascading failure in power systems is difficult because of the many different mechanisms involved; no single model captures all of these mechanisms.
Cotilla-Sanchez, Eduardo, Ghanavati, Goodarz, Hines, Paul D. H., Song, Jiajia   +3 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Load Testing and Analysis of a Large Span Through Simply-Supported Steel Box Arch Bridge

Applied Sciences
To evaluate the true load-bearing capacity and engineering reliability of a large span through a simply supported steel box arch bridge, a load test was conducted on the bridge.
Zhenwei Liu, Weisheng Xu, Qing Xu, Menglin Shi, Yujie Luo   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Determination of the Correlation Dependence Between Static and Dynamic Modulus of Deformation of the Granular Sub-Ballast Layers

Civil and Environmental Engineering
Technological procedures related to the possession of tracks are often under heavy time constraints. Therefore, the attempts to apply dynamic load tests in the process of diagnostics of implemented construction works on modernised sections of railway ...
Ižvolt Libor, Dobeš Peter, Mečár Martin   +2 more
doaj   +1 more source

Study on the Impact Coefficient of Tied Arch Bridge Shock Effect Based on Vehicle-Bridge Coupling

Applied Sciences
In order to study the impact on the shock effect when a high-speed train passes over a concrete-filled steel tube (CFST) tied-arch bridge, a dynamic load test was carried out in the background of the Qinjiang River Bridge in Qinzhou, Guangxi Province, to
Yipu Peng, Hongjun Gan, Zhiyuan Tang, Ning Zhou, Bin Wang   +4 more
doaj   +1 more source

Comparison of analysis and experiment for dynamics of low-contact-ratio spur gears [PDF]

Low-contact-ratio spur gears were tested in NASA gear-noise-rig to study gear dynamics including dynamic load, tooth bending stress, vibration, and noise.
Lin, Hsiang Hsi, Oswald, Fred B., Rebbechi, Brian, Townsend, Dennis P., Zakrajsek, James J.   +4 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Experimental dynamic analysis of the footbridge across Jizera River in Mladá Boleslav

Acta Polytechnica CTU Proceedings
The text of this submitted paper is devoted to the experimental dynamic analysis of the newly designed footbridge across the Jizera River in Mladá Boleslav.
Miroslav Čáp, Vladimír Šána, Michal Polák, Tomáš Plachý   +3 more
doaj   +1 more source