Results 31 to 40 of about 283,176 (245)

Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor [PDF]

European Cells & Materials, 2016
Low back pain originating from intervertebral disc (IVD) degeneration affects the quality of life for millions of people, and it is a major contributor to global healthcare costs. Long-term culture of intact IVDs is necessary to develop ex vivo models of
DH Rosenzweig, R Gawri, J Moir, L Beckman, D Eglin, T Steffen, PJ Roughley, JA Ouellet, L Haglund   +8 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evolution of Permeability and Sensitivity Analysis of Gas-Bearing Coal under Cyclic Dynamic Loading

Applied Sciences
It is imperative to conduct experimental studies on the seepage behavior of gas-bearing coal under cyclic dynamic loading conditions. This paper focuses on the evolution of coal permeability under the combined effects of dynamic loading, static loading ...
Zhongzhong Liu, Yuxuan Liu, Zonghao Wang, Wentao Huang   +3 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Dynamic Wind Loading of Heliostats

SolarPACES Conference Proceedings
A method for the design of heliostats considering dynamic wind loads is presented. The transient FEM simulation is based on a CAD model of the heliostat and a pressure distribution time series measured in a wind tunnel.
Justus Blum, Atli Tobiasson Helmer, Andreas Pfahl   +2 more
doaj   +1 more source

Simplified Method for Defining 2-Dimensional Design Failure Curve of Marine Silty Sand under Dynamic Loading

Journal of Marine Science and Engineering, 2020
Global warming is becoming worse owing to carbon dioxide emissions around the world, and eco-friendly energy for reducing carbon dioxide emissions is gaining importance. Wind power plants are the most representative of the environmentally friendly energy
Su-Won Son, Jong-Chan Yoon, Jin-Man Kim
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Influence of Load Frequency on Cohesive Soil Respond

Geosciences, 2018
The mechanism of cohesive soils response to cycling loading is less investigated compared to cohesionless soils. Multiple load-unload cycles cause significant changes in the structure of cohesive soils, which result in complex behaviour under the given ...
Krystian Kucharczyk, Andrzej Głuchowski, Maciej Miturski, Wojciech Sas   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source