Results 41 to 50 of about 283,176 (245)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

An Experimental Study on Determination of Crack Propagation Energy of Rock Materials Under Dynamic Impact and Static Loading Conditions

Hittite Journal of Science and Engineering, 2019
The Charpy impact test, a widely applied impact strength determination test for various materials such as metals, polymers and cementitious materials was performed to evaluate the crack propagation energy of 13 different granite type rock materials ...
Eren Komurlu
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Characterization and differences of acoustic signals response of semi-circular red sandstone under combined monotonous and cyclic loadings

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
After underground coal mining, rocks are often subjected to tensile damage by the interaction of dynamic and static loadings. The process of rock fracture development under dynamic and static loadings will be released in the form of acoustic energy to ...
Quanle Zou, Chunmei Chen, Zihan Chen, Kang Peng, Hong Lv, Jinfei Zhan   +5 more
doaj   +1 more source

Experimental study on dynamic characteristics of marine soil under multi-frequency loading

Yantu gongcheng xuebao
In order to explore the dynamic characteristics of marine soil and their dynamic influential factors, the laboratory dynamic triaxial tests are carried out on the undisturbed marine soil from an investigated site in Yellow Sea, China by using the GCTS ...
SUN Miaojun 1, WEN Yiling 2, SHAN Zhigang 1, WANG Wei 1, WU Shuaifeng 3, HU Minyun 3, 2
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanical Response Mechanism and Yield Characteristics of Coal Under Quasi-Static and Dynamic Loading

Applied Sciences
During deep mining engineering, coal bodies are subjected to complex geological stresses such as periodic roof pressure and blasting impacts, which may induce mechanical property deterioration and trigger severe rock burst accidents.
Liupeng Huo, Feng Gao, Yan Xing
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source