Results 51 to 60 of about 283,176 (245)
Diurnal Asymmetric Loading Modulates Cell Phenotype in Intervertebral Disc
JOR SpinePurpose This study tested the hypothesis that asymmetric dynamic loading alone or in combination with static loading influences the morphological and biological characteristics of the intervertebral disc (IVD) cells in an ex vivo model.
Ying Zhang +6 more
doaj +1 more source
LONGITUDINAL NON-STATIONARY MOTIONS OF MAGLEV TRAIN
Nauka ta progres transportu, 2019 Purpose. The quality of passenger’s and good’s transportation by a magnetically levitated train (MLT) is a key criterion for evaluating its consumer properties.
V. O. Polyakov, N. M. Khachapuridze
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Dynamically Loading Mobile/Cloud Assemblies [PDF]
, 2017 Distributed applications that span mobile devices, computing clusters, and cloud services, require robust and flexible mechanisms for dynamically loading code. This paper describes lady: a system that augments the .net platform with a highly reliable mechanism for resolving and loading assemblies, and arranges for safe execution of partially trusted ...
Pettersen, Robert +3 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Effects of Principal Stress Rotation on the Fluid-Induced Soil Response in a Porous Seabed
Journal of Marine Science and Engineering, 2019 Principal stress rotation (PSR) is an important feature for describing the stress status of marine sediments subject to cyclic loading. In this study, a one-way coupled numerical model that combines the fluid model (for wave−current interactions ...
Zhengxu Li +3 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Nonlinear EngineeringPile foundation has been widely applied in modern civil engineering due to its excellent performance under complex foundation conditions. However, when subjected to dynamic loads such as waves, tides, and earthquakes, the long-term stability of pile ...
Wang Huimin +3 more
doaj +1 more source