Results 61 to 70 of about 283,176 (245)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Dynamic Loading and the Problem of Strength
Механика машин, механизмов и материалов, 2010 An analysis of dynamic behavior of the threshold characteristics of rock samples with the macrocrack. Found that for each breed there is an optimal duration of loading, which allows to minimize the costs of fracture.
N.F. Morozov +2 more
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
BuildingsThe dynamic fracture behavior of mass concrete is crucial to the dynamic analysis and safety evaluation of concrete dams subjected to strong earthquake shocks in the framework of fracture mechanics. In the presented research, cylindrical specimens with a
Yazhou Zhang +6 more
doaj +1 more source
Dynamic Load Balancing with Tokens [PDF]
2018 IFIP Networking Conference (IFIP Networking) and Workshops, 2018 Efficiently exploiting the resources of data centers is a complex task that requires efficient and reliable load balancing and resource allocation algorithms. The former are in charge of assigning jobs to servers upon their arrival in the system, while the latter are responsible for sharing server resources between their assigned jobs. These algorithms
openaire +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Nauka ta progres transportu, 2017 Purpose. The article is aimed to determine the conditions of a dynamic error formation of contour machine cutting of surface of the real railway wheel flange by the cup-tip tool and propose the ways of reducing the errors. Methodology.
R. P. Pogrebnyak
doaj +1 more source
The Loading Rate Effect on the Fracture Toughness of Marble Using Semicircular Bend Specimens
Geofluids, 2020 A series of dynamic fracture experiments on semicircular bend (SCB) marble specimens were conducted to characterize the loading rate effect using the INSTRON testing machine and the modified SHPB testing system.
Fengqiang Gong +2 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Stress Transmission on Bone and Prosthetic Screws Influenced by Implant Position: A Finite Element Analysis [PDF]
International Journal of Prosthodontics and Restorative DentistryPurpose: To evaluate stress on bone and prosthetic screws as influenced by varying implant positions in a six-implant supported mandibular hybrid prosthesis using finite element method (FEM).
Arpita Paul +5 more
doaj +1 more source