Results 51 to 60 of about 232,484 (246)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Influence of medium adhesion on the mechanical response of PDC impacts

Functional Diamond
Polycrystalline diamond compact (PDC) drill bits are widely employed in ultra-deep oil and gas drilling operations. However, their performance is significantly compromised by mud packing phenomena, primarily caused by rock chip adhesion during impact ...
Dezhong Meng, Chang Chen, Dongxu Hou, Zhongzheng Duan, Tian Tang, Wen Yue   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Effects of Contact Characteristics on Dynamic Response of Planar Mechanical Systems with Lubricated Revolute Joint

Lubricants
In this study, a dynamic response model that incorporates lubricated clearance is developed to examine the evolution of contact and friction in a mechanical system.
Xu Peng, Haoran Zhu, Yang Guo, Xuze Wu, Yu Chen   +4 more
doaj   +1 more source

Excellent ballistic impact resistance of Al0.3CoCrFeNi multi-principal element alloy with unique bimodal microstructure

Scientific Reports, 2021
Multi-principal element alloys represent a new paradigm in structural alloy design with superior mechanical properties and promising ballistic performance.
Saideep Muskeri, Bharat Gwalani, Shristy Jha, Anqi Yu, Philip A. Jannotti, Ravi Sankar Haridas, Brian E. Schuster, Jeffrey T. Lloyd, Rajiv S. Mishra, Sundeep Mukherjee   +9 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Vibration analysis of angle-ply laminates composite plate under thermo-mechanical effect

Journal of Engineering, 2015
The paper presents mainly the dynamic response of an angle ply composite laminated plates subjected to thermo-mechanical loading. The response are analyzed by analytically using Newmark direct integration method with Navier solution, numerically by ANSYS.
Adnan Naji Jamil, Prof. Dr., Rasha Mohammed Hussien, Ass. Lect.   +1 more
doaj  

Mechanical response of structural rock slope under cyclic dynamic disturbance

Meikuang Anquan
In order to study the stability of slopes containing weakly inter bedded rocks under dynamic disturbance, the dynamic response characteristics of rocks with different inclinations under dynamic cyclic disturbance are investigated through indoor ...
Zhouai ZHANG, Yongjiang YU, Yongjun WANG
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source