Results 41 to 50 of about 5,527,376 (298)
Frontiers in Physics, 2022 A dynamic shut-in procedure is commonly adopted after a kick incident in order to build up the wellbore pressure, obtain reservoir information, and thereby handle the gas kick.
Dianyuan Miao +4 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Experimental study on moisture migration law of soils under dynamic slaking conditions
Yantu gongcheng xuebaoUnderstanding the moisture migration mechanisms in railway subgrade soils under dynamic slaking (D-S) is critical for elucidating the formation mechanisms of frost heave and mud pumping defects in heavy-haul railways.
MA Deliang1, , HAN Hongchi 2, DONG Jing 2, LI Teng 2, FENG Huaiping 2, YANG Zhihao 1
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Adhesion Dynamics and Durotaxis in Migrating Cells [PDF]
Biophysical Journal, 2011 When tissue cells are plated on a flexible substrate, durotaxis, the directed migration of cells toward mechanically stiff regions, has been observed. Environmental mechanical signals are not only important in cell migration but also seem to influence all aspects of cell differentiation and development, including the metastatic process in cancer cells.
Harland, Ben, Walcott, Sam, Sun, Sean X.
openaire +3 more sources
Applied Sciences, 2022 Vehicular Edge Computing (VEC) provides users with low-latency and highly responsive services by deploying Edge Servers (ESs) close to applications. In practice, vehicles are usually moving rapidly.
Jiale Zhao +9 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
IEEE Access, 2022 Mobile Edge Cloud (MEC) technology is envisioned to play a key role in next generation mobile networks by supporting low-latency applications using geographically distributed local cloud clusters.
Shalini Choudhury +3 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Dynamic Defense Strategy for Platform Based on Event-driven and Timing Migration [PDF]
Jisuanji gongcheng, 2019 In order to solve the network security defense problem after the intrusion detection system misses detection,using the Moving Target Defense(MTD) technology of the platform layer,this paper designs a new dynamic defense strategy for platforms.Combined ...
CHEN Tongrui, MA Runnian, WANG Gang, WU Weijia
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