Results 141 to 150 of about 543,871 (306)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Discrete Global Sliding Mode Control for Time-Delay Carbon Fiber Multilayer Diagonal Loom

IEEE Access, 2017
In order to overcome the disadvantage that the dynamic sliding mode surface of the discrete global sliding mode control has a too long evolution time, a quick discrete global sliding mode control method is proposed.
Wei Liu, Guowei Xu, Xiuming Jiang
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigation of the dynamic pure-mode-II fracture initiation and propagation of rock during four-point bending test using hybrid finite-discrete element method [PDF]

, 2022
A hybrid finite-discrete element method (FDEM) is proposed to investigate dynamic pure-mode-II fracture behaviors. The transition of continuum to discontinuum was applied to the FDEM through the use of three fracture modes, so that the whole fracture ...
Hongyuan Liu (14742565), Song, Y (15519623), Wu, S (15592154), Fan, Y (15518210), An, H (15622622)   +4 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Thin-disk laser – Power scaling to the kW regime in fundamental mode operation [PDF]

, 2009
A significant reduction of the influence of the thermal lens in thin-disk lasers in high power laser operation mode could be achieved, using dynamically stable resonators. For designing the resonator, investigations of thermally induced phase distortions
Schmid, Elke, Speiser, Jochen, Giesen, Adolf, Spindler, Gerhard, Mende, Jens   +4 more
core  

Second-Order Sliding Mode Guidance Law considering Second-Order Dynamics of Autopilot

Journal of Control Science and Engineering, 2019
Aiming at the requirement that some missiles need to meet certain impact angles when attacking targets, we consider the second-order dynamic characteristics of autopilot, thereby proposing a second-order sliding mode guidance law with impact angle ...
Kuanqiao Zhang, Suochang Yang
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Mixed-mode oscillations with multiple time scales [PDF]

, 2010
Mixed-mode oscillations (MMOs) are trajectories of a dynamical system in which there is an alternation between oscillations of distinct large and small amplitudes.
Desroches, MF, Osinga, HM, Kuehn, Christian, Guckenheimer, J, Wechselberger, Martin, Krauskopf, B   +5 more
core  

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source