Results 1 to 10 of about 1,347,155 (263)

Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action

open access: yesNature Communications, 2021
HER2 acts an oncogenic driver in numerous cancers. Here, the authors design an anti-HER2 biparatopic and tetravalent IgG fusion with inhibitory effects in a xenograft model.
Florian Kast   +14 more
doaj   +1 more source

Modeling Earnings Dynamics [PDF]

open access: yesEconometrica, 2009
In this paper we use indirect inference to estimate a joint model of earnings, employment, job changes, wage rates, and work hours over a career. Our model incorporates duration dependence in several variables, multiple sources of unobserved heterogeneity, job-specific error components in both wages and hours, and measurement error. We use the model to
Ivan Vidangos   +2 more
openaire   +2 more sources

Dynamical affinity in opinion dynamics modeling [PDF]

open access: yesPhysical Review E, 2007
We here propose a model to simulate the process of opinion formation, which accounts for the mutual affinity between interacting agents. Opinion and affinity evolve self-consistently, manifesting a highly non trivial interplay. A continuous transition is found between single and multiple opinion states.
BAGNOLI, FRANCO   +4 more
openaire   +7 more sources

Dynamic Simulation and Parameter Analysis of Weaved Composite Material for Unmanned Aerial Vehicle Parachute Recovery in Deployment Phase

open access: yesCrystals, 2022
Aiming at the parachute recovery of fixed-wing unmanned aerial vehicles, a method of parachute deployment by tractor rocket is proposed. First, the tensile tests were carried out on high-strength polyethylene and brocade silk-weaved composite materials ...
Wenhui Shi   +7 more
doaj   +1 more source

Modeling the public health impact of different meningococcal vaccination strategies with 4CMenB and MenACWY versus the current toddler MenACWY National Immunization Program in Chile

open access: yesHuman Vaccines & Immunotherapeutics, 2021
Invasive meningococcal disease (IMD) is an uncommon yet unpredictable, severe, and life-threatening disease with the highest burden in young children. In Chile, most IMD is caused by meningococcal serogroup B (MenB) and W (MenW) infection. In response to
María Gabriela Graña   +6 more
doaj   +1 more source

Development of a Dynamic Model for Calculating the Kinematic Error and Evaluating Its Effect on the Efficiency of Planetary Mechanisms with Rolling Bodies

open access: yesМеханика машин, механизмов и материалов, 2023
When studying the characteristics of the mechanisms of small-sized drives, an important task is to develop ways to increase the efficiency of the mechanism.
Alexander V. Kapitonov
doaj   +1 more source

Dynamical reduction models [PDF]

open access: yesPhysics Reports, 2003
The report presents an exhaustive review of the recent attempt to overcome the difficulties that standard quantum mechanics meets in accounting for the measurement (or macro-objectification) problem, an attempt based on the consideration of nonlinear and stochastic modifications of the Schroedinger equation.
BASSI, ANGELO, GHIRARDI, GIANCARLO
openaire   +3 more sources

Influence of vehicle acceleration intensity on dual-mass flywheel elements and transmission load

open access: yesTransport Technologies, 2022
Modern high-torque low-speed internal combustion engines (ICEs) generate torsional vibrations close in disturbance frequency to gearboxes natural oscillation frequencies. Effective absorption of such oscillations requires a new torsional vibration damper
Bohdan Kindratskyy   +2 more
doaj   +1 more source

Computational Modeling: Human Dynamic Model [PDF]

open access: yesFrontiers in Neurorobotics, 2020
Improvements in quantitative measurements of human physical activity are proving extraordinarily useful for studying the underlying musculoskeletal system. Dynamic models of human movement support clinical efforts to analyze, rehabilitate injuries.
Lijia Liu   +3 more
openaire   +4 more sources

Optimization of Offshore Wind Power Generation in Response to the 2022 Extreme Drought in Portugal

open access: yesEnergies, 2023
Portugal, in line with the European Union, is aiming for carbon neutrality by 2050 (Net Zero), which implies a transition to sustainable energy sources. Climate change is all too evident, as extreme weather periods are occurring in a cyclical manner with
Fernando M. Camilo   +3 more
doaj   +1 more source

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