Results 201 to 210 of about 1,347,155 (263)

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Multi-region infectious disease prediction modeling based on spatio-temporal graph neural network and the dynamic model. [PDF]

PLoS Comput Biol
Wang X, Jin Z.
europepmc   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew, Maryam Kargaran, Maik Rothe, Andreas Deistung, Dietrich Stoevesandt, Walter A. Wohlgemuth, David Strube, Thomas Kendzierski, Anna Katharina Kölsch, Maurits Gerhard Abraham Heuschen, Markus Otto, Alexander Mensch   +11 more
wiley   +1 more source

A process-based dynamic model for succinic acid production by <i>Actinobacillus succinogenes</i>: regulatory role of ATP/ADP balance. [PDF]

Front Microbiol
Salucci E, Cartenì F, Giannino F, de Alteriis E, Raganati F, Mazzoleni S.   +5 more
europepmc   +1 more source

An individual-based dynamic model to assess interventions to mitigate opioid overdose risk. [PDF]

Harm Reduct J
Gallant K, Lukeman R.
europepmc   +1 more source

A Bayesian Dynamic Model-Based Adaptive Design for Oncology Dose Optimization in Phase I/II Clinical Trials. [PDF]

Pharm Stat
Qiu Y, Li M.
europepmc   +1 more source

Forecasting influenza epidemics in China using transmission dynamic model with absolute humidity. [PDF]

Infect Dis Model
Chen X, Tao F, Chen Y, Cheng J, Zhou Y, Wang X.   +5 more
europepmc   +1 more source

Correction to: A dynamic model of gene activation in response to hypoxia accounting for both HIF-1 and HIF-2. [PDF]

Brief Funct Genomics
europepmc   +1 more source

Current and Future Cost Burden of Ischemic Stroke in Australia: Dynamic Model.

Neuroepidemiology
Abebe TB, Ilomaki J, Livori A, Bell JS, Morton JI, Ademi Z.   +5 more
europepmc   +1 more source