Results 91 to 100 of about 4,044,594 (272)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Continuous Time Structural Equation Modeling with R Package ctsem
Journal of Statistical Software, 2017 We introduce ctsem, an R package for continuous time structural equation modeling of panel (N > 1) and time series (N = 1) data, using full information maximum likelihood.
Charles C. Driver +2 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
, 2016 We discuss Bayesian analysis of multivariate time series with dynamic factor models that exploit time-adaptive sparsity in model parametrizations via the latent threshold approach.
Nakajima, Jouchi, West, Mike
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Testing the sustainability of the Croatian public debt with dynamic models [PDF]
Financial Theory and Practice, 2011 Almost all macroeconomic indicators change upon shocks influenced by the global financial crisis that has also spilled over to the public sector, seriously threatening fiscal sustainability. The aim of this paper is to estimate public debt sustainability
Petar Sopek
doaj
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Elman neural network for modeling and predictive control of delayed dynamic systems
Archives of Control Sciences, 2016 The objective of this paper is to present a modified structure and a training algorithm of the recurrent Elman neural network which makes it possible to explicitly take into account the time-delay of the process and a Model Predictive Control (MPC ...
Wysocki Antoni, Ławryńczuk Maciej
doaj +1 more source
Dynamic Optimization in Two-Party Models [PDF]
The goal of this paper is to study the problem of optimal dynamic policy formulation with competing political parties. We study a general class of problems, in which the two competing political parties have quadratic intertemporal objective functions ...
Jeffrey Sachs +2 more
core
Covariance estimation for multivariate conditionally Gaussian dynamic linear models
, 2007 In multivariate time series, the estimation of the covariance matrix of the observation innovations plays an important role in forecasting as it enables the computation of the standardized forecast error vectors as well as it enables the computation of ...
Anderson +44 more
core +1 more source