Results 171 to 180 of about 4,044,594 (272)

Performance of five dynamic models in predicting tuberculosis incidence in three prisons in Thailand. [PDF]

PLoS One
Mahawan N, Rattananupong T, Sri-Uam P, Jiamjarasrangsi W.   +3 more
europepmc   +1 more source

Learning and Predicting from Dynamic Models for COVID-19 Patient Monitoring. [PDF]

Stat Sci, 2022
Wang Z, Bowring MG, Rosen A, Garibaldi B, Zeger S, Nishimura A.   +5 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Comparison Between Dynamic Models for Predicting Response to Corticosteroids in Alcohol-Associated Hepatitis: A Global Cohort Study. [PDF]

Aliment Pharmacol Ther
Idalsoaga F, Díaz LA, Guizzetti L, Dunn W, Mehta H, Arnold J, Ayares G, Mortuza R, Mahli G, Islam AH, Sarin SK, Maiwall R, Zhang W, Qian S, Simonetto D, Singal AK, Elfeki MA, Ramirez-Cadiz C, Cabezas J, Echavarría V, Cots MV, La Tijera MFH, Abraldes JG, Al-Karaghouli M, Jalal PK, Ali Ibrahim M, García-Tsao G, Goyes D, Skladaný L, Havaj DJ, Sulejova K, Selcanova SA, Rincón D, Shah VH, Kamath PS, Arrese M, Bataller R, Arab JP.   +37 more
europepmc   +1 more source

Comparative assessment of viral dynamic models for SARS-CoV-2 for pharmacodynamic assessment in early treatment trials. [PDF]

Br J Clin Pharmacol, 2022
Agyeman AA, You T, Chan PLS, Lonsdale DO, Hadjichrysanthou C, Mahungu T, Wey EQ, Lowe DM, Lipman MCI, Breuer J, Kloprogge F, Standing JF.   +11 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

From disorganized data to emergent dynamic models: Questionnaires to partial differential equations. [PDF]

PNAS Nexus
Sroczynski DW, Kemeth FP, Georgiou AS, Coifman RR, Kevrekidis IG.   +4 more
europepmc   +1 more source

Modular assembly of dynamic models in systems biology. [PDF]

PLoS Comput Biol, 2021
Pan M, Gawthrop PJ, Cursons J, Crampin EJ.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

I watch SEM: continuous time dynamic models with N≥1 smart watch data. [PDF]

Ind Health
Dormann C, Diener O.
europepmc   +1 more source