The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation. [PDF]
Nat Commun, 2023 Meier M +19 more
europepmc +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Cyclohexane Oxidative Dehydrogenation on Graphene-Oxide-Supported Cobalt Ferrite Nanohybrids: Effect of Dynamic Nature of Active Sites on Reaction Selectivity. [PDF]
ACS Catal, 2023 Kadam SA +17 more
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen +7 more
wiley +1 more source
Response to-Tracking the role of sphingolipids in MS: The dynamic nature of ceramide synthases. [PDF]
Mult Scler, 2022 Bhargava P, Haughey N, Calabresi PA.
europepmc +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang +8 more
wiley +1 more source
Implications of Quantum Logic to the Notion of Transcendence
Pensamiento. Revista de Investigación e Información Filosófica, 2015 This article attempts to study the notion of Transcendence from the perspective of Quantum Mechanics. The Laws of Physics reveal that nature is dynamic and it is understood in terms of mathematical models and relations.
Jerome Manyahi, Francis Xavier
doaj
Inverse Versus Normal Behavior of Interactions, Elucidated Based on the Dynamic Nature with QTAIM Dual-Functional Analysis. [PDF]
Int J Mol Sci, 2023 Nakanishi W +5 more
europepmc +1 more source
Application of GRASP (General Rotorcraft Aeromechanical Stability Program) to nonlinear analysis of a cantilever beam [PDF]
The General Rotorcraft Aeromechanical Stability Program (GRASP) was developed to analyse the steady-state and linearized dynamic behavior of rotorcraft in hovering and axial flight conditions. Because of the nature of problems GRASP was created to solve,
Hinnant, Howard E., Hodges, Dewey H.
core +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source