Results 91 to 100 of about 446,026 (280)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

PFC-FDEM multi-scale cross-platform numerical simulation of thermal crack network evolution and SHTB dynamic mechanical response of rocks

International Journal of Mining Science and Technology
Underground engineering in extreme environments necessitates understanding rock mechanical behavior under coupled high-temperature and dynamic loading conditions.
Yue Zhai, Shaoxu Hao, Shi Liu, Yu Jia
doaj   +1 more source

Customized Dynamic Load Balancing for a Network of Workstations

Journal of Parallel and Distributed Computing, 1996
Load balancing involves assigning to each processor work proportional to its performance, minimizing the execution time of the program. Although static load balancing can solve many problems (e.g., those caused by processor heterogeneity and non uniform loops) for most regular applications, the transient external load due to multiple users on a network
M.J. Zaki, null Wei Li, S. Parthasarathy
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Data Load Balancing in Heterogeneous Dynamic Networks

, 2016
Data load balancing is a challenging task in the P2P systems. Distributed hash table (DHT) abstraction, heterogeneous nodes, and non uniform distribution of objects are the reasons to cause load imbalance in structured P2P overlay networks. Previous works solved the load balancing problem by assuming the homogeneous capabilities of nodes, unawareness ...
Mirrezaei, Seyed Iman, Shahparian, Javad
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Identification of failure behaviors of underground structures under dynamic loading using machine learning

Journal of Rock Mechanics and Geotechnical Engineering
Understanding the dynamic responses of hard rocks is crucial during deep mining and tunneling activities and when constructing nuclear waste repositories.
Chun Zhu, Yingze Xu, Manchao He, Yujing Jiang, Murat Karakus, Lihua Hu, Yalong Jiang, Fuqiang Ren   +7 more
doaj   +1 more source

A statistical mechanical approach to the Payne effect in filled rubbers

eXPRESS Polymer Letters, 2015
In this paper we apply and discuss some new aspects to the steric interaction of filler particles in reinforced elastomers under dynamic mechanical loading conditions.
G. Heinrich, T. A. Vilgis
doaj   +1 more source

Dynamic User Equilibrium (DUE) [PDF]

, 2006
The quantitative analysis of road network traffic performed through static assignment models yields the transport demand-supply equilibrium under the assumption of within-day stationarity.
GENTILE, Guido, K. NOEKEL, MESCHINI, LORENZO   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source