Results 41 to 50 of about 95,886 (246)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Use of PDA Dynamic Test Results in Determining the Bearing Capacity of Single Pile in Marine Structures by Artificial Neural Networks

نشریه مهندسی دریا, 2020
In this study, using the results of 100 PDA dynamic loading tests obtained from different projects and using three types of artificial neural networks (ANN), the loading capacity of a single pile is evaluated.
Saeed Ghaffarpour Jahromi, Mohammad Sharafuddin   +1 more
doaj  

Modeling the infiltration rate of wastewater infiltration basins considering water quality parameters using different artificial neural network techniques

Engineering Applications of Computational Fluid Mechanics, 2022
Predicting the infiltration rate (IR) of treated wastewater (TWW) is essential in controlling clogging problems. Most researchers that predict the IR using neural network models considered the characteristics parameters of soil without considering  those
Ghada Abdalrahman, Sai Hin Lai, Pavitra Kumar, Ali Najah Ahmed, Mohsen Sherif, Ahmed Sefelnasr, Kwok Wing Chau, Ahmed Elshafie   +7 more
doaj   +1 more source

Constitutive modelling of fabric effect on sand liquefaction

Journal of Rock Mechanics and Geotechnical Engineering, 2023
Sand liquefaction under static and dynamic loading can cause failure of embankments, slopes, bridges and other important infrastructure. Sand liquefaction in the seabed can also cause submarine landslides and tsunamis.
Zhiwei Gao, Dechun Lu, Yue Hou, Xin Li
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Scraper Face Conveyors Dynamic Load Control

Записки Горного института, 2019
The task of controlling the dynamic loading of scraper face conveyors (SC) is considered and the unsatisfactory state of loading of mechanical and electrical components of the SC is recorded. The possibility of the appearance of a self-oscillatory nature
E. K. Eshchin
doaj   +1 more source

Dynamic Mechanical Properties of Slag Mortar with Alkali-Resistant Glass Fiber

Buildings, 2022
To investigate the influence of alkali-resistant glass fiber on the dynamic mechanical properties and microstructure of slag cement mortar (SCM), five SCM blocks with different volumes of alkali-resistant glass fiber (0%, 0.25%, 0.5%, 0.75%, and 1%) were
Haibin Ma, Shaofan Yang, Ying Xu, Peiyuan Chen, Liang Wang   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source