Results 61 to 70 of about 95,886 (246)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

PFC-FDEM multi-scale cross-platform numerical simulation of thermal crack network evolution and SHTB dynamic mechanical response of rocks

International Journal of Mining Science and Technology
Underground engineering in extreme environments necessitates understanding rock mechanical behavior under coupled high-temperature and dynamic loading conditions.
Yue Zhai, Shaoxu Hao, Shi Liu, Yu Jia
doaj   +1 more source

Customized Dynamic Load Balancing for a Network of Workstations

Journal of Parallel and Distributed Computing, 1996
Load balancing involves assigning to each processor work proportional to its performance, minimizing the execution time of the program. Although static load balancing can solve many problems (e.g., those caused by processor heterogeneity and non uniform loops) for most regular applications, the transient external load due to multiple users on a network
M.J. Zaki, null Wei Li, S. Parthasarathy
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Data Load Balancing in Heterogeneous Dynamic Networks

, 2016
Data load balancing is a challenging task in the P2P systems. Distributed hash table (DHT) abstraction, heterogeneous nodes, and non uniform distribution of objects are the reasons to cause load imbalance in structured P2P overlay networks. Previous works solved the load balancing problem by assuming the homogeneous capabilities of nodes, unawareness ...
Mirrezaei, Seyed Iman, Shahparian, Javad
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Identification of failure behaviors of underground structures under dynamic loading using machine learning

Journal of Rock Mechanics and Geotechnical Engineering
Understanding the dynamic responses of hard rocks is crucial during deep mining and tunneling activities and when constructing nuclear waste repositories.
Chun Zhu, Yingze Xu, Manchao He, Yujing Jiang, Murat Karakus, Lihua Hu, Yalong Jiang, Fuqiang Ren   +7 more
doaj   +1 more source

A statistical mechanical approach to the Payne effect in filled rubbers

eXPRESS Polymer Letters, 2015
In this paper we apply and discuss some new aspects to the steric interaction of filler particles in reinforced elastomers under dynamic mechanical loading conditions.
G. Heinrich, T. A. Vilgis
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source