Results 91 to 100 of about 692,102 (303)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

A Noise-Robust Method with Smoothed \ell_1/\ell_2 Regularization for Sparse Moving-Source Mapping

, 2016
The method described here performs blind deconvolution of the beamforming output in the frequency domain. To provide accurate blind deconvolution, sparsity priors are introduced with a smooth \ell_1/\ell_2 regularization term. As the mean of the noise in
Mars, Jérôme I., Nicolas, Barbara, Oudompheng, Benoit, Pham, Mai Quyen   +3 more
core   +3 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Traffic model uncertainty for noise mapping [PDF]

After the European Parliament published the Environmental Noise Directive 2002/49/CE (END) and the implementation by Member States in their own legislation, they had to use the same evaluation methods to analyse noise pollution and same indicators ...
ASCARI, ELENA
core  

Array atomic force microscopy for real-time multiparametric analysis. [PDF]

, 2019
Nanoscale multipoint structure-function analysis is essential for deciphering the complexity of multiscale biological and physical systems. Atomic force microscopy (AFM) allows nanoscale structure-function imaging in various operating environments and ...
Azam, Farooq, Cauwenberghs, Gert, Head, Brian P, Herum, Kate M, John, Scott, Lal, Ratnesh, Lee, Joon, Liu, Zhaowei, Lo, Yu-Hwa, Ma, Qian, McCulloch, Andrew D, Patel, Nirav, Tang, Hanmei, Wang, Chonghe, Wang, Jun, Wang, Shanshan, Xu, Sheng, Yang, Qingqing, Yen, Tony M   +18 more
core   +1 more source

Inferring causality from noisy time series data

, 2016
Convergent Cross-Mapping (CCM) has shown high potential to perform causal inference in the absence of models. We assess the strengths and weaknesses of the method by varying coupling strength and noise levels in coupled logistic maps.
Fusaroli, Riccardo, Mønster, Dan, Roepstorff, Andreas, Sherson, Jacob F., Tylén, Kristian   +4 more
core   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source

Solution to the SLAM Problem in Low Dynamic Environments Using a Pose Graph and an RGB-D Sensor

Sensors, 2014
In this study, we propose a solution to the simultaneous localization and mapping (SLAM) problem in low dynamic environments by using a pose graph and an RGB-D (red-green-blue depth) sensor.
Donghwa Lee, Hyun Myung
doaj   +1 more source