Results 81 to 90 of about 371,718 (256)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Obesity and labour market outcomes in Italy: a dynamic panel data evidence with correlated random effects. [PDF]

Eur J Health Econ, 2023
Pacifico A.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Impact of Environmental Technologies and Environmental Policy Stringency on Environmental Degradation

Ekonomi, Politika & Finans Araştırmaları Dergisi
The increase in global warming and environmental pollution accelerates ecological degradation and prompts governments worldwide to adopt policies aimed at addressing environmental challenges while maintaining economic growth.
Özen Akçakanat, Gökhan Özkul, Ozan Özdemir, Muhammed Kasım   +3 more
doaj   +1 more source

An Analysis of the Effective Factors on the Iran’s Trade Convergence with the Selected Regional Blocks (Application of a Gravity Model) [PDF]

Faslnāmah-i Pizhūhish/Nāmah-i Iqtisādī, 2014
The long time passed since the commencement of globalization process has caused those countries who were not seeking achievement of a free market within the framework globalization to take benefit from regional-orientation as a solution for their foreign
Amir Reza Soori
doaj  

The Impact of Country Risk Management on Economic Growth in the Selected OIC Countries

برنامه‌ریزی و بودجه, 2021
The economic performance to reduce country risk, in which the existing economic, social, and political conditions negatively affect the capacity to repay foreign debt and attract foreign direct investment, is one of the prominent issues in economic ...
Farzam Sajjadieh Khajaviee, Sadegh Bakhtiari, Sara Ghobadi   +2 more
doaj  

Factors associated with changes in the objectively measured physical activity among Japanese adults: A longitudinal and dynamic panel data analysis. [PDF]

PLoS One, 2023
Watanabe D, Murakami H, Gando Y, Kawakami R, Tanisawa K, Ohno H, Konishi K, Sasaki A, Morishita A, Miyatake N, Miyachi M.   +10 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Overlapping Delta and Omicron Outbreaks During the COVID-19 Pandemic: Dynamic Panel Data Estimates. [PDF]

JMIR Public Health Surveill, 2022
Lundberg AL, Lorenzo-Redondo R, Hultquist JF, Hawkins CA, Ozer EA, Welch SB, Prasad PVV, Achenbach CJ, White JI, Oehmke JF, Murphy RL, Havey RJ, Post LA.   +12 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source