Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Risk analysis of wind farm connection to existing grids using dynamic line rating
, 2018 Dynamic Line Rating (DLR) is a technology that allows extending capacity of existing power lines for transportation higher electrical power capacity from production site to the customer.
Morozovska, Kateryna, +5 more
core +1 more source
Performance of Reinforced Reactive Powder Concrete Beam-Column Joints under Cyclic Loads
Advances in Civil Engineering, 2018 An experimental research was carried out to investigate the seismic performance and shear strength of reactive powder concrete interior beam-column joints subjected to reverse cyclic loads.
Wenzhong Zheng, Dehong Wang, Yanzhong Ju
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
A Dynamic Power Management Schema for Multi-Tier Data Centers
, 2023 An issue of great concern as it relates to global warming is power consumption and efficient use of computers especially in large data centers. Data centers have an important role in IT infrastructures because of their huge power consumption. This thesis
Azimzadeh, Aryan +1 more
core
Dynamic and Leakage Power-Composition Profile Driven Co-Synthesis for Energy and Cost Reduction
, 2004 Recent research has shown that combining dynamic voltage scaling (DVS) and adaptive body bias (ABB) techniques achieve the highest reduction in embedded systems energy dissipation [1].
Al-Hashimi, Bashir M +2 more
core +1 more source
A Novel Method for Estimating Pitch and Yaw of Rotating Projectiles Based on Dynamic Constraints
Sensors, 2019 This paper addresses the difficult problem of measuring the attitude of a high-spinning projectile and presents a novel method for estimating the pitch and yaw angles of the projectile in flight.
Liangliang An +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Five-Hole Pressure Probe Based on Integrated MEMS Fiber-Optic Fabry-Perot Sensors
MicromachinesThe five-hole pressure probe based on Micro-Electro-Mechanical Systems (MEMS) technology is designed to meet the needs of engine inlet pressure measurement.
Yumiao Song +5 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source