Results 81 to 90 of about 9,052,591 (257)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

Offshore wind farm layout optimization accounting for participation in secondary reserve markets [PDF]

open access: yesWind Energy Science
Wind farm layout optimization usually aims at maximizing annual energy production by placing wind turbines in a strategic way to avoid wake losses. However, this might not lead to optimal profits because of the volatility of electricity prices. Moreover,
T.-H. Nguyen   +5 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

open access: yesFEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés   +2 more
wiley   +1 more source

Hybrid Power Balancing Method of Modular Power Converters to Achieve Enhanced Efficiency and Dynamic Performance

open access: yes, 2021
In general, the master-slave output power balancing method has widely been used to stabilize parallelconnected modular power converters. However, it cannot consider the performance deviation among the modular power converters due to different stress and ...
Jung, Jee-Hoon   +2 more
core  

Comparing the paths of Hedgehog release in artificial and natural settings

open access: yesFEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Power for Service

open access: yes, 1944
Includes the history of the Puget Sound Power and Light Company power plants and ...
Puget Sound Power and Light Company
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study on Strong Earthquake Failure of Single-Layer Spherical Reticulated Shell Structures with Central Suspended Equipment

open access: yesBuildings
In recent years, there have been more and more engineering examples of installing giant suspended equipment (e.g., central suspended LED display) in large-span space structures; however, there are fewer studies on the seismic response and strong-seismic ...
Wenliang Li, Xudong Zhi
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Dynamic Risk Assessment System for Power System Based on Multi-source Information of the Ubiquitous Power Internet of Things

open access: yesZhongguo dianli, 2019
In view of the current situation that it is difficult for the power regulation and control center to take the multi-source information into account for the effective dynamic risk assessment of power grid, this paper points out the challenges and ...
Shenhua WANG   +4 more
doaj   +1 more source

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