Results 91 to 100 of about 3,055,551 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Influence of Hybrid Fibers on Workability, Mechanical and Dynamic Properties of Ultra-High Performance Concrete

Applied Sciences
Ultra-high performance concretes (UHPCs) have been widely used in the construction industry due to their high strength and long-term performance. The purpose of this article is to review the literature on UHPC that contained at least two types of hybrid ...
Krystian Błaszczyk, Piotr Smarzewski
doaj   +1 more source

Dynamic Properties of Microresonators with the Bionic Structure of Tympanic Membrane

Sensors, 2020
The structure of a microresonator will affect the vibration characteristics and the performance of the system. Inspired by the structural characteristics of the human tympanic membrane, this paper proposed a microresonator with the bionic structure of a ...
Yongpeng Tai, Kai Zhou, Ning Chen
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Stability of the solutions of the Gross-Pitaevskii equation

, 2005
We examine the static and dynamic stability of the solutions of the Gross-Pitaevskii equation and demonstrate the intimate connection between them. All salient features related to dynamic stability are reflected systematically in static properties.
A. D. Jackson, C. J. Pethick, E. Lundh, G. M. Kavoulakis   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Asymptotic Properties of Optimal Trajectories in Dynamic Programming

, 2010
We prove in a dynamic programming framework that uniform convergence of the finite horizon values implies that asymptotically the average accumulated payoff is constant on optimal trajectories.
Sorin, Sylvain, Venel, Xavier, Vigeral, Guillaume   +2 more
core   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dynamic Response of Masonry Structures to Temperature Variations: Experimental Investigation of a Brick Masonry Wall

Sensors
Structural health monitoring (SHM) is essential for preserving historical and modern infrastructure by tracking dynamic properties such as frequencies and mode shapes.
Daniele Pellegrini, Alberto Barontini, Nuno Mendes, Paulo B. Lourenço   +3 more
doaj   +1 more source

Dynamics of simulated water under pressure

, 1999
We present molecular dynamics simulations of the SPC/E model of water to probe the dynamic properties at temperatures from 350 K down to 190 K and pressures from 2.5GPa (25kbar) down to -300MPa (-3kbar).
Sciortino, Francesco, Stanley, H. Eugene, Starr, Francis W.   +2 more
core   +1 more source