Results 141 to 150 of about 18,365,131 (347)

Tailored ensembles of neural networks optimize sensitivity to stimulus statistics

open access: yes, 2019
The dynamic range of stimulus processing in living organisms is much larger than a single neural network can explain. For a generic, tunable spiking network we derive that while the dynamic range is maximal at criticality, the interval of discriminable ...
Levina, Anna   +3 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Experimental Investigation of Characteristics and Development of Nonlinearity Models for FR1-Range Radio-Frequency Amplifiers

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники
Experimental studies of nonlinear properties of low-power radio-frequency amplifiers similar to those used in 4G/5G mobile communication equipment of the FR1 frequency range are carried out.
V. I. Mordachev   +5 more
doaj   +1 more source

Precise Implementation of CDTA

open access: yesAdvances in Electrical and Electronic Engineering, 2017
The Current Differencing Transconductance Amplifier (CDTA) is a popular active building block for analog signal processing. Since it is not available as a commercial IC, most of the CDTA applications are verified only via simulations or the CDTA is ...
Dalibor Biolek, Jiri Vavra
doaj   +1 more source

Signal phase switches offer greater dynamic range [PDF]

open access: yes, 1970
Circuit, placed in the signal path of a closed-loop receiver to modulate telemetered data in the 10-MHz spectrum, improves signal-to-noise ratio by 3 db in a communication receiver.
Crow, R. B.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Red fluorescent cAMP indicator with increased affinity and expanded dynamic range

open access: yesScientific Reports, 2018
cAMP is one of the most important second messengers in biological processes. Cellular dynamics of cAMP have been investigated using a series of fluorescent indicators; however, their sensitivity was sub-optimal for detecting cAMP dynamics at a low ...
Yusaku Ohta   +3 more
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Multi‐defect‐engineering in ZnO/GO heterostructures for optoelectronic synaptic devices with ultra‐high dynamic range and low energy consumption

open access: yesInfoMat
In artificial visual systems, optimizing the dynamic range (DR) of optoelectronic synapses is essential for achieving robust and environment‐adaptive perception.
Zhiyao Zheng   +12 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

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