Results 191 to 200 of about 491 (246)

Design and Engineering of an Artificial Bifunctional N‐Deacetylase/N‐Sulfotransferase for the Biosynthesis of N‐Sulfated Heparosan

open access: yesAdvanced Science, EarlyView.
An artificial bifunctional N‐deacetylase/N‐sulfotransferase was engineered in Escherichia coli by combining screened N‐deacetylases with an NST domain. The integrated engineering strategy improved enzyme performance. The optimized enzyme efficiently converted heparosan into N‐sulfated heparosan, addressing a key bottleneck in microbial heparin ...
Xintong Xi   +8 more
wiley   +1 more source

A Closed‐Loop Framework for Inverse Design: Dynamic Training and Intelligent Optimization for Heterostructured Materials

open access: yesAdvanced Science, EarlyView.
To accelerate the inverse design of heterostructured metal matrix composites, a closed‐loop scientific machine learning framework integrates continual learning prediction with NSGA‐II‐PMCP optimization. The framework maps microstructural descriptors to strength, toughness, and modulus, expands high‐quality Pareto solutions, and guides experimentally ...
Zhiyan Zhong   +11 more
wiley   +1 more source

Desiderata for a biomedical knowledge network: opportunities, challenges and future directions. [PDF]

open access: yesBioinform Adv
Wu C   +7 more
europepmc   +1 more source

Spatial Dynamic Searchable Encryption with Forward Security

Lecture Notes in Computer Science, 2020
Nowadays, spatial search services bring unprecedented convenience in people’s daily life (e.g., location-based services, social networking) and are becoming more and more popular. To protect the privacy of outsourcing data, several schemes have been proposed to achieve secure search over encrypted spatial databases.
Yinbin Miao, Ximeng Liu, Wang Xiangyu
exaly   +2 more sources

Home - About - Disclaimer - Privacy