Results 221 to 230 of about 730 (270)

Design of Block-Scrambling-Based privacy protection mechanism in healthcare using fusion of transfer learning models with Hippopotamus optimization algorithm. [PDF]

Sci Rep
Elhessewi GMS, Alzahrani MY, Alamgeer M, Darem AA, Albalawneh D, Alqahtani M, Al Sadig M, Alanazi S.   +7 more
europepmc   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

IoT data security in outsourced databases: A survey of verifiable database. [PDF]

Heliyon
Chen A, Yu S, Yang X, Huang D, Ren Y.
europepmc   +1 more source

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

Retrieval Integrity Verification and Multi-System Data Interoperability Mechanism of a Blockchain Oracle for Smart Healthcare with Internet of Things (IoT) Integration. [PDF]

Sensors (Basel)
Zhou Z, Chen L, Zhao Y, Yang X, Han Z, He Z.   +5 more
europepmc   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, EarlyView.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source

A Phase‐Resolved Geometric Deep Learning Framework Maps Structural Determinants of Disease‐Associated Protein Aggregation and Guides Suppressor Design

Advanced Science, EarlyView.
SKALE 2.0 maps disease‐associated protein aggregation as a phase‐resolved structural process, linking mutation‐induced geometric perturbations to nucleation, elongation, and suppressor design. Across neurodegenerative proteins, the framework reveals cryptic aggregation vulnerabilities, separates phase‐concordant and phase‐switching mutations, and ...
Jia Shen Sio, Wei Xuan Wilson Loo, Yan Shan Loo, Wen Xin Tan, Hui Xuan Lim, Huitao Liu, Chen Seng Ng   +6 more
wiley   +1 more source

Desiderata for a biomedical knowledge network: opportunities, challenges and future directions. [PDF]

Bioinform Adv
Wu C, Liu H, Flannick J, Musen MA, Su AI, Hunter LE, Powers TM, Wu CH.   +7 more
europepmc   +1 more source

Towards Secure Internet of Things: A Coercion-Resistant Attribute-Based Encryption Scheme with Policy Revocation. [PDF]

Entropy (Basel)
Zhai Y, Wang T, Zhou Y, Zhu F, Yang B.
europepmc   +1 more source