Results 141 to 150 of about 3,330,790 (253)

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

open access: yesAngewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej   +20 more
wiley   +2 more sources

The Key Technologies and Technological Evolution Mechanisms of Robotic Systems for Fracture Reduction Surgery

open access: yesAdvanced Intelligent Systems, EarlyView.
This review traces three decades of technological evolution in robot‐assisted fracture reduction systems, from early robotic concepts to clinically oriented platforms. Key advances in robotic architecture, navigation, path planning, interaction control, and surgical integration are summarized, while current translational challenges and future ...
Shaolong Kuang   +5 more
wiley   +1 more source

Dual‐View Representation Learning for Deployable Humanoid Whole‐Body Control

open access: yesAdvanced Intelligent Systems, EarlyView.
Humanoid robots must learn control from limited onboard sensing, although simulation provides richer training‐only states. DVP learning pairs these views of each simulated motion and aligns their latent control features inside the policy‐learning loop. This direct, deployment‐aware supervision accelerates learning while the deployed policy relies only ...
Haolin Song   +3 more
wiley   +1 more source

Objectives and Key Results–Driven Multiagent Framework for Mechanical Design and Simulation

open access: yesAdvanced Intelligent Systems, EarlyView.
Objectives and key results (OKR)‐agent, an OKR‐driven multiagent framework, turns a plain‐language engineering goal into completed mechanical simulations. Three peer agents—supervisor, modeler, and simulator—share a compact board of OKR and coordinate external molecular dynamics (MD) and finite‐element solvers through a standardized tool interface. The
Jie Tian   +10 more
wiley   +1 more source

Balancing Exploration and Exploitation Through a Sequential Hybrid of Roach Infestation and Mayfly Algorithms for Constrained Engineering Design Optimization

open access: yesAI &Innovation, EarlyView.
ABSTRACT Maintaining an effective balance between exploration and exploitation is essential during optimization processes, from mathematical functions to more complex problems such as constrained engineering design optimization, particularly when addressing highly nonlinear issues with numerous local optima and strict feasibility requirements.
Enrique Lizárraga   +3 more
wiley   +1 more source

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