Results 41 to 50 of about 640,483 (247)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Aerodynamic and stability analysis of the Safat01 aircraft [PDF]

open access: yesScientific Technical Review, 2015
This paper aimed to predict aerodynamic & stability data for the Safat01 aircraft. Because of its economic and time efficiency, the Digital DATCOM program has been used to predict the stability and control derivatives for the subsonic, low angle of ...
Qurashi Rania   +3 more
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Electrochemical and Mechanical Properties of Asphalt Concrete Modified by Carbon Microfibers

open access: yesInternational Journal of Electrochemical Science, 2020
Carbon microfibers (CMFs) due to their flexibility, durability, conductivity and superior strength have great potential as reinforcement materials in asphalt concrete.
Lijie Ma, Chunfeng Yang, Jishu Sun
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Experimental Study on Small-Scale Shake Table Testing of Cable-Stiffened Single-Layer Spherical Latticed Shell

open access: yesBuildings
The cable-stiffened single-layer latticed shell is an innovative structural design that achieves a perfect balance between lightweight and stability by combining cables and a latticed shell. However, the study on dynamic response and failure mechanism of
Ying Zhao   +7 more
doaj   +1 more source

The Impact of Sloshing Liquids on Ship Stability for Various Dimensions of Partly Filled Tanks [PDF]

open access: yesTransNav, 2013
Liquid sloshing phenomenon taking place in partly filled ships' tanks directly affects the stability of a vessel. However, only static calculations are carried out onboard ships nowadays and static transfer of liquid weight is taken into account in the ...
Przemyslaw Krata
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

STABILITY AND GENERICITY IN DYNAMICAL SYSTEMS [PDF]

open access: yes, 1980
A general reference to this subject, with examples, written about the summer of 1967 is [7], (reported in a recent Bourbaki seminar by C. Godbillon). Here I will try to emphasize developments since. An important source of much of this more recent work should appear in the immediate future in [1].
openaire   +1 more source

Home - About - Disclaimer - Privacy