Results 261 to 270 of about 235,695 (358)

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

open access: yesChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo   +4 more
wiley   +1 more source

The Politics of Policy Robustness: A Central Paradox and Computational Review of Adaptive Policymaking

open access: yesPublic Administration and Development, EarlyView.
ABSTRACT Policy robustness, that is, the capacity of policies to sustain performance across diverse and uncertain futures, is increasingly considered a core objective of public policymaking. Although adaptive policymaking is widely promoted as an approach to achieving policy robustness, it suffers from a central paradox highlighted by theories of the ...
Ola G. El‐Taliawi, Nihit Goyal
wiley   +1 more source

Land data assimilation of satellite‐based surface soil moisture: Impact on atmospheric simulations over the contiguous United States

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
Soil Moisture Active Passive soil moisture retrievals are assimilated into a land surface model and the resulting land reanalysis product is used to initialise the land component of coupled land‐atmosphere experiments. We show that the local impact of land data assimilation on the atmosphere is influenced by two factors: the magnitude by which it ...
Zdenko Heyvaert   +6 more
wiley   +1 more source

Digital Twin Simulations Toolbox of the Nitrogen‐Vacancy Center in Diamond

open access: yesAdvanced Quantum Technologies, EarlyView.
The Nitrogen‐vacancy (NV) center in diamond is a key platform within quantum technologies. This work introduces a Python based digital‐twin of the NV, where the spin dynamics of the system is simulated without relying on commonly used approximations, such as the adoption of rotating frame. The digital‐twin is validated through three different examples,
Lucas Tsunaki   +3 more
wiley   +1 more source

Large-scale stochastic simulation of open quantum systems. [PDF]

open access: yesNat Commun
Sander A   +8 more
europepmc   +1 more source

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