Results 51 to 60 of about 542,689 (312)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The Shear Strength of Granular Materials with Dispersed and Non-Dispersed Oversized Particles [PDF]

, 2013
Soils containing dispersed and non-dispersed large particles (greater than # 4 sieve) form part of many engineered fills, glacial tills, debris flows, and residual soil deposits.
Seminsky, Leanna
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Global subjective memorability and the strength-based mirror effect [PDF]

, 2009
Between-list manipulations of memory strength through repetition commonly generate a mirror effect, with more hits, and fewer false alarms for strengthened items. However, this pattern is rarely seen with within-list manipulations of strength.
Perfect, Timothy J., Perfect, T.J., Higham, Philip A., Bruno, D., Bruno, Davide, Higham, P.A.   +5 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Dynamic mechanical response and failure patterns of ore rocks with varying grades

矿业科学学报
This study investigates the dynamic mechanical response and energy dissipation mechanism of ore rock with different grades from the Baiyun Ebo West Mine under impact loading.
DU Wenxiu, WANG Yu, YANG Xu, WANG Kai, YANG Leijun, YANG Yang, ZUO Jinjing, ZHANG Xiang   +7 more
doaj   +1 more source

ANALYSIS OF DYNAMIC LOAD STRENGTH OF WIND TURBINE ROOT BOLT UNDER TURBULENCE MODEL [PDF]

, 2021
As an important connecting and fastening part of wind turbine blade,blade root bolt plays an important role in the operation of wind turbine. In this paper,the connecting bolt between blade and pitch bearing of 2 MW wind turbine is taken as the research ...
HAN Wen, CHEN ChangZheng
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigation of corrosion effect on the dynamic strength of some structural steels

Zaštita Materijala, 2015
By corrosion effect, the surface of the metal becomes so rough that there are reduction in metal strength as a consequence of nicking. It should be added that the continuing effects of corrosion produces deep and sharp notches in the metal.
Branko Pejović, Vladan Mićić, Milorad Tomić   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source