Results 171 to 180 of about 16,890,236 (293)

Dynamic optimization research of crank-rocker mechanism considering hinge clearance and flexible components

Jixie chuandong
ObjectiveHinge clearances and flexible components significantly affect the dynamic characteristics of mechanical systems, yet relevant optimization studies remain limited.
SUN Changlin, LIU Qiang, MA Fusheng, LI Xiao   +3 more
doaj  

Domain Knowledge Constrained Symbolic Regression for Optimising Dermal Drug Formulations. [PDF]

Pharm Res
Zhang Y, Wang X, Tsaoulidis D, Chen T.
europepmc   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

The Cognition to Surrogate Motherhood for Public in Taiwan

, 2009
[[abstract]]“Surrogate Motherhood” is one of the hot topics that people have discussed all over the world. The foreign countries have already had many experiences of the surrogate motherhood over 20 years, but the policy of the surrogate motherhood has ...
Chang Lung Chaio
core  

Thalamic modulation of cortical linearity across arousal states. [PDF]

Sci Adv
Müller EJ, Munn BR, Baracchini G, Fulcher BD, Medel V, Redinbaugh MJ, Saalmann YB, Wehrman JJ, Sanders RD, Brunton BW, Brunton SL, Shine JM.   +11 more
europepmc   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Evaluation of Myocardial Blood Flow Using ¹⁸F-flurpiridaz PET: Established Applications with Pharmacologic Stress and Roadmap for Exercise Stress Implementation. [PDF]

Curr Cardiol Rep
Ali FZ, Slomka PJ, Packard RRS.
europepmc   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Grey-box modeling framework for consolidated bioprocessing systems: an endpoint-guided approach. [PDF]

Bioresour Bioprocess
Yeboah MK, Söffker D.
europepmc   +1 more source