Results 51 to 60 of about 16,890,236 (293)

Testing of a biofidelic leg surrogate and an innovative test bench for the multi-axial dynamic evaluation of sport knee braces

, 2023
reservedA new biofidelic leg surrogate will be designed and tested. The leg surrogate will be mounted on a test bench with the addition of a load system that will simulate the contraction of the quadriceps femoris.
FAVERO, GIANMARCO
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Development of a surrogate-based vehicle dynamic model to reduce computational delays in a driving simulator

, 2016
The development of a real-time driving simulator involves highly complex integrated and interdependent subsystems that require a large amount of computational time.
Nima, Fouladi Nejad, Mohd. Taib, Jamaludin, Fouladinejad, Nariman, Abdul Jalil, Mohamad Kasim   +3 more
core   +2 more sources

An efficient dynamic reliability method for maglev vehicle-bridge systems and its application in random controller parameters analysis

Journal of Low Frequency Noise, Vibration and Active Control
This article presents an efficient method for analyzing the dynamic reliability of maglev vehicle-bridge coupled systems by combining a theoretical model with an adaptive surrogate model and the probability density evolution method (PDEM).
Lidong Wang, Qingrong Li, Xun Zhang, Xiumeng Bu, Peng Hu, Yan Han   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A framework for surrogate-based aerodynamic optimization [PDF]

, 2011
At DLR, an optimization framework combining different CFD solvers, Design of Experiment methods, optimization algorithms, and various surrogate modeling methodologies with sample refinement strategies for efficient surrogate-based global optimization is ...
Görtz, Stefan, Li, Chunna, Brezillon, Joël   +2 more
core  

Propagating Parameter Uncertainty in Power System Nonlinear Dynamic Simulations Using a Koopman Operator-Based Surrogate Model [PDF]

, 2022
We propose a Koopman operator-based surrogate model for propagating parameter uncertainties in power system nonlinear dynamic simulations. First, we augment a priori known state-space model by reformulating parameters deemed uncertain as pseudo-state ...
Xu, Yijun, Netto, Marcos, Mili, Lamine M., Mili, Lamine, Yijun Xu, Marcos Netto, Lamine Mili   +6 more
core   +1 more source

Aerodynamic Optimization of Transonic Rotor Using Radial Basis Function Based Deformation and Data-Driven Differential Evolution Optimizer

Aerospace, 2022
The complicated flow conditions and massive design parameters bring two main difficulties to the aerodynamic optimization of axial compressors: expensive evaluations and numerous optimization variables. To address these challenges, this paper establishes
Yi Liu, Jiang Chen, Jinxin Cheng, Hang Xiang   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source