Results 111 to 120 of about 612,889 (331)

Dynamic Urban Environmental Exposures on Depression and Suicide (NEEDS) in the Netherlands: a protocol for a cross-sectional smartphone tracking study and a longitudinal population register study

open access: yesBMJ Open, 2019
Introduction Environmental exposures are intertwined with mental health outcomes. People are exposed to the environments in which they currently live, and to a multitude of environments along their daily movements and through their residential ...
Marco Helbich
doaj   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

open access: yesAdvanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni   +14 more
wiley   +1 more source

Dynamic second language support for Web-based information systems [PDF]

open access: yes, 1998
Non-native speakers of English are faced with the 'second language problem' when required to interact with English-based information systems. This paper describes strategies for addressing the problem, which arises through difficulties in comprehension ...
Lepouras, G., Weir, G.R.S.
core  

Hsa_circ_0026782 Acts as a “Molecular Break” of CREB1‐Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression

open access: yesAdvanced Science, EarlyView.
Model for the role of hsa_circ_0026782/p‐CREB1 (Ser142) played in keloid. Hsa_circ_0026782 is derived from back‐splicing of ITGA7 exon 4. When hsa_circ_0026782 binds to CREB1, the exposure of the bZIP domain and dimerization of CREB1 are promoted (upper left).
Xin‐Cao Zhong   +10 more
wiley   +1 more source

Non-Conservative Diffusion and its Application to Social Network Analysis [PDF]

open access: yes, 2011
The random walk is fundamental to modeling dynamic processes on networks. Metrics based on the random walk have been used in many applications from image processing to Web page ranking.
Ghosh, Rumi   +4 more
core  

JNets: Exploring networks by integrating annotation

open access: yesBMC Bioinformatics, 2009
Background A common method for presenting and studying biological interaction networks is visualization. Software tools can enhance our ability to explore network visualizations and improve our understanding of biological systems, particularly when these
Pinney John W   +2 more
doaj   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning   +11 more
wiley   +1 more source

Video Conferencing Tool [PDF]

open access: yes, 2009
Video Conferencing Tool (VCT) is a web-based video chat application that allows users anywhere in the world to join real-time streaming video chat rooms. This product is similar to social networking sites that allow web-based video conferencing. The main
Blesson, Sapna
core   +1 more source

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