Results 51 to 60 of about 644,969 (331)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Personalized Job Opportunity Finder powered by Web Scraping [PDF]

MATEC Web of Conferences
"Personalized Job Opportunity Finder powered by Web Scraping" research presents a comprehensive exploration the development and implementation of an innovative Job Portal, aiming to redefine the traditional job search experience.
Akshay Budharapu, Arun Kumar Ravula, Ramyasri Thudum, Arpitha Kosuna   +3 more
doaj   +1 more source

Harnessing Non‐Covalent Protein–Protein Interaction Domains for Production of Biocatalytic Materials Systems

Advanced Functional Materials, EarlyView.
Non‐covalent protein–protein interactions mediated by SH3, PDZ, or GBD domains enable the self‐assembly of stable and biocatalytically active hydrogel materials. These soft materials can be processed into monodisperse foams that, once dried, exhibit enhanced mechanical stability and activity and are easily integrated into microstructured flow ...
Julian S. Hertel, Maria Alessandra Martini, Marius Stoeckle, Annika J. Weber, Kersten S. Rabe, Christof M. Niemeyer   +5 more
wiley   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Webpage Biomechanics of Physical Exercise

Cultura Física y Deportes de Guantánamo, 2016
The principle of the unity of the scientific and ideological character of the pedagogic process states that it must be structured on the most advanced basis of the contemporary science and in correspondence with our ideology. The fundamental objective of
Maury Rodríguez-Rodríguez, María Adela Ceballos-Rubio, Orestes Batista-La Rosa   +2 more
doaj  

OntologyWidget – a reusable, embeddable widget for easily locating ontology terms

BMC Bioinformatics, 2007
Background Biomedical ontologies are being widely used to annotate biological data in a computer-accessible, consistent and well-defined manner. However, due to their size and complexity, annotating data with appropriate terms from an ontology is often ...
Skene JH Pate, Jin Heng, Zachariah Zachariah K, Nitzberg Michael, Wymore Farrell, Beauheim Catherine C, Ball Catherine A, Sherlock Gavin   +7 more
doaj   +1 more source

WPMSD: A Malicious Script Detection Method Inspired by the Process of Immunoglobulin Secretion [PDF]

International Journal of Computational Intelligence Systems, 2011
Inspired by the process of immunoglobulin secretion in biological body, we present a Web Page Malicious Script Detection Method (WPMSD). In this paper, Firstly, the basic definitions of artificial immune items are given.
Hui Zhao, Jie Zeng, Yuanquan Shi, Jian Qin, Wen Chen   +4 more
doaj   +1 more source

Critical Dynamics of Burst Instabilities in the Portevin-Le Chatelier Effect

, 2001
We investigate the Portevin-Le Chatelier effect (PLC), by compressing Al-Mg alloys in a very large deformation range, and interpret the results from the viewpoint of phase transitions and critical phenomena.
A. H. Cottrell, A. H. Cottrell, A. Portevin, B. Cheng, B. Miller, C. J. Olson, C. Reichhardt, C. Reichhardt, C. Reichhardt, D. Sornette, E. Kolb, F. Mertens, Franco Nori, G. Ananthakrishna, Gianfranco D'Anna, J. Friedel, J. P. Hirth, J. P. Poirier, J. Weertman, M. A. Lebyodkin, P. G. McCormick, P. Hähner, P. Lukáč, S. Field, Y. Estrin   +24 more
core   +1 more source

Weaving aspects into web service orchestrations [PDF]

, 2005
Web Service orchestration engines need to be more open to enable the addition of new behaviours into service-based applications. In this paper, we illus- trate how, in a BPEL engine with aspect-weaving ca- pabilities, a process-driven application ...
Courbis, C., Finkelstein, A.
core   +2 more sources

Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase

Advanced Functional Materials, EarlyView.
Cell‐based therapies require advanced strategies to enhance cell delivery and bioactivity. Cell membrane engineering offers an avenue to impart new functions to delivered cells to boost their viability and function. Here, an artificial membrane‐binding transglutaminase is generated and biophysically characterized.
Rosalia Cuahtecontzi Delint, Tao Li, Kapil D. Patel, Will H. Zhang, Ben M. Carter, Graham J. Day, Adam W. Perriman   +6 more
wiley   +1 more source