Results 41 to 50 of about 38,899 (233)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Integrability and chaotic dynamics in nonlinear dispersive stochastic model

Results in Applied Mathematics
This paper focuses on obtaining exact solutions and dynamical analysis of the stochastic real-valued Ginzburg–Landau equation driven by multiplicative Itô noise.
Muhammad Aziz-ur-Rehman, Muhammad Moneeb Tariq, Ayesha Zafar, Muhammad Bilal Riaz   +3 more
doaj   +1 more source

Fractional-order chaotic system with hyperbolic function

Advances in Mechanical Engineering, 2019
In this article, we study bistability, multiscroll, and symmetric properties of fractional-order chaotic system with cubic nonlinearity. The system is configured with hyperbolic function consisting of a parameter “ g .” By varying the parameter “ g ...
G Gugapriya, Prakash Duraisamy, Anitha Karthikeyan, B Lakshmi   +3 more
doaj   +1 more source

Statistical properties of Lorenz like flows, recent developments and perspectives

, 2014
We comment on mathematical results about the statistical behavior of Lorenz equations an its attractor, and more generally to the class of singular hyperbolic systems.
Anosov D. V., Anosov D. V., Bautista S., Boichenko V. A., Bonatti C., Bowen R., Devaney R., Hopf E., Leonov G. A., Leonov G. A., Maria José Pacifico, Philipp W., Robinson C., Robinson C., Ruelle D., Sinaĭ J. G., Stefano Galatolo, Vitor Araujo   +17 more
core   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

The Synthesis of Arbitrary Stable Dynamics in Non-linear Neural Networks II: Feedback and Universality [PDF]

, 1992
We wish to construct a realization theory of stable neural networks and use this theory to model the variety of stable dynamics apparent in natural data.
Cohen, Michael A.
core   +1 more source

The Jungle Universe [PDF]

, 2014
In this paper, we exploit the fact that the dynamics of homogeneous and isotropic Friedmann-Lemaitre universes is a special case of generalized Lotka-Volterra system where the competitive species are the barotropic fluids filling the Universe.
Carletti, Timoteo, Füzfa, André, Guedezounme, Laurent, Mélot, Laurence, Perez, Jérôme   +4 more
core   +5 more sources

A Robust Adaptive One‐Sample‐Ahead Preview Super‐Twisting Sliding Mode Controller

International Journal of Adaptive Control and Signal Processing, EarlyView.
Block Diagram of the Robust Adaptive One‐Sample‐Ahead Preview Super‐Twisting Sliding Mode Controller. ABSTRACT This article introduces a discrete‐time robust adaptive one‐sample‐ahead preview super‐twisting sliding mode controller. A stability analysis of the controller by Lyapunov criteria is developed to demonstrate its robustness in handling both ...
Guilherme Vieira Hollweg, Paulo Jefferson Dias de Oliveira Evald, Shivam Chaturvedi, Hilton Abilio Gründling, Rodrigo Varella Tambara, Wencong Su   +5 more
wiley   +1 more source

Additive Gaussian Process Regression for Predictive Design of High‐Performance, Printable Silicones

Advanced Engineering Materials, EarlyView.
A chemistry‐aware design framework for tuning printable polydimethylsiloxane (PDMS) for vat photopolymerization (VPP) is developed using additive Gaussian process (GP) modeling. Polymer network mechanics informs variable groupings, feasible formulation constraints, and interaction variables.
Roxana Carbonell, Martha Leach, Hongtao Song, Carolyn Seepersad   +3 more
wiley   +1 more source