Results 51 to 60 of about 12,450,949 (319)

Originator dynamics [PDF]

Journal of Theoretical Biology, 2009
We study the origin of evolution. Evolution is based on replication, mutation, and selection. But how does evolution begin? When do chemical kinetics turn into evolutionary dynamics? We propose "prelife" and "prevolution" as the logical precursors of life and evolution. Prelife generates sequences of variable length.
Manapat, Michael L., Ohtsuki, Hisashi, Bürger, Reinhard, Nowak, Martin   +3 more
openaire   +4 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Simplicial quantum dynamics

, 2011
Present-day quantum field theory can be regularized by a decomposition into quantum simplices. This replaces the infinite-dimensional Hilbert space by a high-dimensional spinor space and singular canonical Lie groups by regular spin groups.
Baugh J, Blatt J M, Bohm D, Bopp F, C F von Weizsaecker Komplementaritat und Logik I-II, Connes A, David Finkelstein, Dennis Marks, Dirac P A M, Feynman R P Personal communication ca, Finkelstein D, Finkelstein D, Galiautdinov A A, Gerstenhhaber M, Hestenes D, Inönü E, Kleinert H, Madore J, Mermin N D, Palev T D, Penrose R, Saller H, Saller H, Salom I, Segal I E, Selesnick S A, Shiri-Garakani, Snyder H P, Stoilova N I, Stückelberg E C G, Tavel M, Vilela Mendes R, Wess J, Yang C N   +33 more
core   +1 more source

Exploring Network Structure, Dynamics, and Function using NetworkX

Proceedings of the Python in Science Conference, 2008
NetworkX is a Python language package for exploration and analysis of networks and network algorithms. The core package provides data structures for representing many types of networks, or graphs, including simple graphs, directed graphs, and graphs with
A. Hagberg, D. Schult, P. Swart, JM Hagberg   +3 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Dirac's Constrained Hamiltonian Dynamics from an Unconstrained Dynamics

, 2003
We derive the Hamilton equations of motion for a constrained system in the form given by Dirac, by a limiting procedure, starting from the Lagrangean for an unconstrained system.
Batlle, Dirac, Dirac, Gitman, Hanson, Heinz J. Rothe, Henneaux, Lusanna, Sudarshan, Sundermeyer   +9 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Generalized Competing Glauber-type Dynamics and Kawasaki-type Dynamics

, 2002
In this article, we have given a systematic formulation of the new generalized competing mechanism: the Glauber-type single-spin transition mechanism, with probability p, simulates the contact of the system with the heat bath, and the Kawasaki-type spin ...
Attila Szolnoki, B.C.S. Grandi, B.C.S. Grandi, B.C.S. Grandi, B.C.S. Grandi, B.C.S. Grandi, Han Zhu, Han Zhu, Jian-yang Zhu, Jian-Yang Zhu, Jian-Yang Zhu, Jian-Yang Zhu, K. Kawasaki, Ma Yuqiang, Mauricio Godoy, R.J. Glauber, S. Bekhechi, T. Tome, Yang Zhou, Yu-qiang Ma   +19 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source