Results 41 to 50 of about 934,318 (260)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Dipolar hydroclimate pattern changes in southwest China during the last deglaciation

npj Climate and Atmospheric Science
Deciphering the driving forces behind spatial heterogeneity of regional hydroclimate changes is significant for developing strategies for water management.
Gang Xue, Yanhong Zheng, Shouyi Huang, Guangming Meng, Mei He, Yajie Wei, Ruoxin Li, Youfeng Ning, John Dodson, Hai Cheng, Yanjun Cai   +10 more
doaj   +1 more source

How to Make a Barranco: Modeling Erosion and Land-Use in Mediterranean Landscapes

Land, 2015
We use the hybrid modeling laboratory of the Mediterranean Landscape Dynamics (MedLanD) Project to simulate barranco incision in eastern Spain under different scenarios of natural and human environmental change.
C. Michael Barton, Isaac Ullah, Arjun Heimsath   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Spatial and temporal disaggregation of anthropogenic CO2 emissions from the City of Cape Town

South African Journal of Science, 2015
This paper describes the methodology used to spatially and temporally disaggregate carbon dioxide emission estimates for the City of Cape Town, to be used for a city-scale atmospheric inversion estimating carbon dioxide fluxes. Fossil fuel emissions were
Alecia Nickless, Robert J. Scholes, Ed Filby   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Multi-stage evolution of mesoscale warm eddies in the Kuroshio Extension: a case study based on data-assimilative modeling

Frontiers in Marine Science
Mesoscale warm eddy shedding from the Kuroshio Extension (KE) is highly variable, and its evolution during the life cycle is affected by KE perturbations.
Liwen Zhang, Liwen Zhang, Yikai Xu, Yikai Xu, Wenlong Ma, Wenlong Ma, Xingliang Jiang, Xingliang Jiang, Zhijin Li, Zhijin Li   +9 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A protocol for high-quality sectioning for tree-ring anatomy

Frontiers in Plant Science
Quantitative wood anatomy (QWA), which involves measuring wood cell anatomical characteristics commonly on dated tree rings, is becoming increasingly important within plant sciences and ecology.
Marina V. Fonti, Marina V. Fonti, Georg von Arx, Georg von Arx, Maryline Harroue, Loïc Schneider, Loïc Schneider, Daniel Nievergelt, Daniel Nievergelt, Jesper Björklund, Jesper Björklund, Rashit Hantemirov, Rashit Hantemirov, Vladimir Kukarskih, Vladimir Kukarskih, Cyrille B.K. Rathgeber, Nadja-Tamara Studer, Nadja-Tamara Studer, Patrick Fonti, Patrick Fonti   +19 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source