Results 261 to 270 of about 23,741 (299)
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International Journal of Peptide and Protein Research, 1984
Dynorphin‐(1–13) (Dyn‐(1–13)) and its analogs substituted by single introduction of Ala in positions 1–11 were synthesized by the solid‐phase method and purified by high pressure liquid chromatography. Relative potencies of the synthetic compounds were determined by their ability to inhibit electrically‐evoked contractions of the guinea pig ileum (GPI)
Andree Turcotte +3 more
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Dynorphin‐(1–13) (Dyn‐(1–13)) and its analogs substituted by single introduction of Ala in positions 1–11 were synthesized by the solid‐phase method and purified by high pressure liquid chromatography. Relative potencies of the synthetic compounds were determined by their ability to inhibit electrically‐evoked contractions of the guinea pig ileum (GPI)
Andree Turcotte +3 more
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European Journal of Pharmacology, 1984
Peptides deriving from the proenkephalin B precursor were studied in the Ungerstedt rotational model after their unilateral injection into the substantia nigra. Dynorphin (DYN)-(1-17), DYN-(1-13) and DYN-(1-8) in 0.1-10 micrograms doses induced marked contralateral rotation.
M, Herrera-Marschitz +4 more
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Peptides deriving from the proenkephalin B precursor were studied in the Ungerstedt rotational model after their unilateral injection into the substantia nigra. Dynorphin (DYN)-(1-17), DYN-(1-13) and DYN-(1-8) in 0.1-10 micrograms doses induced marked contralateral rotation.
M, Herrera-Marschitz +4 more
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Brain Research, 1984
The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
N, Zamir, M, Palkovits, M J, Brownstein
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The distribution of immunoreactive (ir)-dynorphin A1-8 (Dyn A1-8) in 78 microdissected rat brain areas as well as in the neurointermediate lobe of pituitary gland was determined using a highly specific radioimmunoassay. The highest concentrations of Dyn A1-8 in brain were found in substantia nigra (673.8 fmol/mg protein) and lateral preoptic area (565 ...
N, Zamir, M, Palkovits, M J, Brownstein
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The Journal of Pharmacology and Experimental Therapeutics, 1991
In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t ...
J J, Rady, J M, Fujimoto, L F, Tseng
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In recent publications we have proposed that dynorphin (Dyn) A(1-17) functions as an antianalgesic modulator to oppose opioid-induced antinociception in mice. In the present experiments using the tail-flick response in mice, other Dyns [Dyn A(1-8), Dyn A(1-13), Dyn A(2-17), Dyn B and alpha- and beta-neoendorphin] when administered intrathecally (i.t ...
J J, Rady, J M, Fujimoto, L F, Tseng
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Tissue distribution of a dynorphin-processing endopeptidase
Endocrinology, 1993A number of peptide hormones and neurotransmitters require post-translational processing at monobasic cleavage sites. An enzymatic activity capable of processing prodynorphin at a monobasic processing site has been previously reported in rat brain and bovine pituitary. This dynorphin (Dyn)-converting enzyme (DCE) activity is capable of converting Dyn-B-
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Dynorphin immunoreactivity in pituitary.
Advances in biochemical psychopharmacology, 1982Tissue ir-dynorphin has been shown to be associated with three components separable by gel filtration. Similar components were found in both pituitary and brain, although there are differences in the relative amounts of each component in each tissue.
B M, Cox, E R, Baer, A, Goldstein
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