Results 101 to 110 of about 3,486 (173)

Single‐Cell Insights Into Macrophage Subtypes in Pulmonary Infections

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This review highlights the dynamic plasticity of macrophages during pulmonary infections and proposes an integrative framework defining six functional subtypes: Inflam‐Ms, Hub‐Ms, Reg‐Ms, Prolif‐Ms, Memory‐Ms, and Senesc‐Ms. Single‐cell omics delineate their distinct roles in homeostasis and infection, refining our understanding of macrophage ...
Zhaoheng Lin, Yuxiao Zheng, Yu Zhong, Hongyan Wang   +3 more
wiley   +1 more source

Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss Associated with Primary-Cilia Defects. [PDF]

, 2016
Cone-rod degeneration (CRD) belongs to the disease spectrum of retinal degenerations, a group of hereditary disorders characterized by an extreme clinical and genetic heterogeneity.
Andréasson, S., Arsenijevic, Y., Balzano, S., Bedoni, N., Blazaki, S.V., Boldt, K., Cisarova, K., Cremers, F.P., Decembrini, S., Di Gioia, S.A., El Zaoui, I., Farinelli, P., Giangreco, B., Khan, M.I., Kjellström, U., Mbefo, M.K., Messina, A., Micheal, S., Moulin, A.P., Nikopoulos, K., Plainis, S., Rivolta, C., Roepman, R., Royer-Bertrand, B., Tsika, C., Tsilimbaris, M.K., Ueffing, M.   +26 more
core   +2 more sources

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma. [PDF]

, 2015
横紋筋肉腫におけるゲノム・エピゲノム異常の全体図を解明 -横紋筋肉腫を4群に分類-. 京都大学プレスリリース. 2015-07-03.Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome ...
Aburatani, Hiroyuki, Akiyama, Masaharu, Chiba, Kenichi, Hanada, Ryoji, Hayashi, Yasuhide, Hoshino, Noriko, Hosoi, Hajime, Igarashi, Takashi, Kato, Keisuke, Kato, Motohiro, Koh, Katsuyoshi, Miyachi, Mitsuru, Miyano, Satoru, Nagae, Genta, Nishimura, Riki, Nomura, Yuko, Ogawa, Seishi, Oka, Akira, Okita, Hajime, Okuno, Yusuke, Sato, Yusuke, Seki, Masafumi, Shimamura, Teppei, Shiozawa, Yusuke, Shiraishi, Yuichi, Souzaki, Ryota, Taguchi, Tomoaki, Takita, Junko, Tanaka, Hiroko, Tanaka, Yukichi, Yoshida, Kenichi   +30 more
core   +1 more source

Variation in the Ovine Abomasal Lymph Node Transcriptome between Breeds Known to Differ in Resistance to the Gastrointestinal Nematode [PDF]

, 2015
Texel lambs are known to be more resistant to gastrointestinal nematode (GIN) infection than Suffolk lambs, with a greater ability to limit infection. The objectives of this study were to: 1) profile the whole transcriptome of abomasal lymph node tissue ...
A Pichlmair, A Takaoka, AC Zambon, AFT Amarante, Albin M. Ahmed, AM Ahmed, Amanda Lohan, B Chessa, B Ewing, B Good, B Langmead, Barbara Good, Bojlul Bahar, Bryan Markey, D Coltman, FW Schwaiger, G Sayers, G Sayers, H Kato, H Li, H Poeck, J Buitkamp, J Hellemans, J Mugambi, J Pemberton, Jai Mehta, James P. Hanrahan, JJ Rios, John Browne, M Hassan, M O'Brien, M Stear, M Yoneyama, M Yoneyama, MD Robinson, MD Robinson, NA Barrett, OM Keane, OM Keane, Orla M. Keane, P Baruah, Paul McGettigan, R Cagliani, S Biacchesi, S Kawamoto, S Saijo, S Uematsu, ST Hollmig, Suryaprakash Sambhara, TA Kraus, TE Spencer, Torres Sweeney, Y Inoshima   +52 more
core   +2 more sources

Comparison of ovarian mRNA expression levels in wild and hatchery-produced greater amberjack Seriola dumerili

Scientific Reports
The greater amberjack Seriola dumerili is a promising candidate for aquaculture production. This study compares the ovary transcriptome of greater amberjack sampled in the wild (WILD) with hatchery-produced breeders reared in aquaculture sea cages in the
Anna Lavecchia, Caterina De Virgilio, Luigi Mansi, Caterina Manzari, Constantinos C. Mylonas, Ernesto Picardi, Chrysovalentinos Pousis, Sharon N. Cox, Gianluca Ventriglia, Rosa Zupa, Graziano Pesole, Aldo Corriero   +11 more
doaj   +1 more source

Exome sequencing identifies novel dysferlin mutation in a family with pauci-symptomatic heterozygous carriers

BMC Medical Genetics, 2018
Background We investigated a South African family of admixed ancestry in which the first generation (G1) developed insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced severe unexpected symptoms of ...
Mahjoubeh Jalali-Sefid-Dashti, Melissa Nel, Jeannine M. Heckmann, Junaid Gamieldien   +3 more
doaj   +1 more source

The Popeye Domain Containing Genes and Their Function in Striated Muscle

, 2016
The Popeye domain containing (POPDC) genes encode a novel class of cAMP effector proteins, which are abundantly expressed in heart and skeletal muscle. Here we will review their role in striated muscle as deduced from work in cell and animal models and ...
Brand, T, Ferlini, A, French, V, Schindler, RFR, Scotton, C   +4 more
core   +2 more sources

Effective treatment of edema and endothelial barrier dysfunction with imatinib [PDF]

, 2012
Background-Tissue edema and endothelial barrier dysfunction as observed in sepsis and acute lung injury carry high morbidity and mortality, but currently lack specific therapy.
Aman, J., Bezu, J. van, Damanafshan, A., Eringa, E.C., Groeneveld, A.B.J., Hinsbergh, V.W.M. van, Huveneers, S., Nieuw Amerongen, G.P. van, Vogel, S.M., Vonk Noordegraaf, A.   +9 more
core   +1 more source

Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq [PDF]

, 2015
Oral squamous cell carcinoma (OSCC) is a prevalent cancer with poor prognosis. Most OSCC progresses via a non-malignant stage called dysplasia. Effective treatment of dysplasia prior to potential malignant transformation is an unmet clinical need.
Chalkley, R, Chengot, P, Conway, C, Daly, C, Droop, A, Graham, JL, Rabbitts, P, Ross, L, Stead, LF   +8 more
core   +3 more sources

Brain of miyoshi myopathy/dysferlinopathy patients presents with structural and metabolic anomalies

Scientific Reports
Miyoshi myopathy/dysferlinopathy (MMD) is a rare muscle disease caused by DYSF gene mutations. Apart from skeletal muscles, DYSF is also expressed in the brain.
Petra Hnilicova, Marian Grendar, Monika Turcanova Koprusakova, Alzbeta Trancikova Kralova, Jana Harsanyiova, Martin Krssak, Ivica Just, Nadezda Misovicova, Martina Hikkelova, Jan Grossmann, Peter Spalek, Iveta Meciarova, Egon Kurca, Norbert Zilka, Kamil Zelenak, Wolfgang Bogner, Martin Kolisek   +16 more
doaj   +1 more source