Results 41 to 50 of about 2,516,635 (116)

Mechanisms Underlying the Initiation and Termination of Collective Cell Migration: Perspectives for Understanding Development and Cancer Metastasis

BioEssays, Volume 48, Issue 4, April 2026.
How collective cell migration starts and stops is a fundamental question but remains poorly understood. This review discusses the distinct mechanisms in in vivo models and cancer metastasis that define the regulatory pathways and collective features governing the initiation and termination of collective cell migration.
Guangxia Miao
wiley   +1 more source

Multiorgan Molecular Landscape of Severe COVID‐19 Revealed by Consensus Gene Signatures and RAB8B Targeting

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Severe COVID‐19 involves hyperinflammation and multiorgan pathology, but consistent gene signatures remain elusive. We aimed to identify consensus transcriptomic signatures and molecular mechanisms in severe COVID‐19. We performed an integrative analysis of 39 studies spanning 11 tissue types, 1551 bulk RNA‐seq samples, and over 2 million ...
Jonathan Peña Avila, Peter Park, Youvika Singh, Paulo P. Amaral, Ícaro Castro, Felipe Ten‐Caten, Viviane Schuch, André N. A. Gonçalves, Jeevan Giddaluru, Mauro César Cafundó Morais, Rodrigo L. T. Ogava, Thiago Lubiana, Gabriel Amoroso de Castro, Rodrigo Aquino, Luiz Durão, Júlia Raspante Martins, Leandro Jimenez, André G. Costa‐Martins, Patrícia Gonzalez‐Dias, Thiago Dominguez Crespo Hirata, Thomaz Lüscher Dias, Débora Guerra Peixe, Adriana Simizo, Juan Carlo Santos e Silva, Amanda Pereira Vasconcelos, Marcelo Berçot Rodrigues, Bianca G. Castelucci, João Victor Virgillio‐da‐Silva, Larissa Menezes, Pedro M. Moraes‐Vieira, Otavio Cabral‐Marques, Helder I. Nakaya   +31 more
wiley   +1 more source

Assessment of physiological parameters in the application of a double adeno-associated virus 9 with a codon-optimized DYSF gene for limb girdle muscular dystrophy type R2 [PDF]

Introduction: Gene therapy for Myoshi myopathy is extremely relevant, as it may become the first pathogenetic treatment for dysferlinopathy. The aim of this study was to study the efficacy and safety of the use of a genetic construct, the AAV9-DYSF-DV3 ...
Andrey А. Manuylov, Mikhail V. Korokin, Alexandra I. Radchenko, Elеna V. Kuzubova, Ivan A. Yakovlev, Ariana M. Korokina, Natalia V. Koroleva, Roman V. Deev, Arthur A. Isaev   +8 more
core   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source

Identification of a novel heterozygous DYSF variant in a large family with a dominantly‐inherited dysferlinopathy

, 2022
Aims Dysferlinopathy is an autosomal recessive muscular dystrophy, caused by bi-allelic variants in the gene encoding dysferlin (DYSF). Onset typically occurs in the second to third decade and is characterised by slowly progressive skeletal muscle ...
Schaefer, A.M., Laing, N.G., Ravenscroft, G., Hayhurst, H., Folland, C., Trajanoski, D., Johnsen, R., Guglieri, M., Barresi, R., Lamont, P.J., Davis, M.R., Botero Gomez, A., Moore, U., Straub, V.   +13 more
core  

Implementing a Tiered Genetic Testing Strategy for Muscular Dystrophies in Morocco: From Targeted Assays to Exome Sequencing

Molecular Genetics &Genomic Medicine, Volume 14, Issue 3, March 2026.
Targeted routine testing combined with NGS approaches enabled effective genetic diagnosis of muscular dystrophies in Moroccan patients, with nearly half of cases resolved by first‐line testing and additional diagnoses obtained through targeted sequencing and whole‐exome sequencing.
Yasmina Rahmuni, Ilham Ratbi, Jaber Lyahyai, Imane Cherkaoui Jaouad, Ourayna Batta, Aziza Sbiti, Maryem Sahli, Omar Askander, Zineb Rchiad, Abdelaziz Sefiani   +9 more
wiley   +1 more source

Analysis of the DYSF Mutational Spectrum in a Large Cohort of Patients [PDF]

, 2008
International audienceDysferlinopathies belong to the heterogeneous group of autosomal recessive muscular dystrophies. Mutations in the gene encoding dysferlin (DYSF) lead to distinct phenotypes, mainly Limb Girdle Muscular Dystrophy type 2B (LGMD2B) and
Pellissier, Jean, Elisabeth Ollagnon-Roman, Françoise Chapon, Bevilacqua, Jorge, Attarian, Shahram, Jorge A. Bevilacqua, Jon Andoni Urtizberea, Shahram Attarian, Nguyen, Karine, Figarella-Branger, Dominique, Ollagnon-Roman, Elisabeth, Karine Nguyen, El Hadi Hammouda, Pellissier, Jean-François, France Leturcq, Nicolas Lévy, Jean-François Pellissier, Bruno Eymard, Eymard, Bruno, Dominique Figarella-Branger, Jean Pouget, Krahn, Martin, Guillaume Bassez, Isabelle Richard, Bernard, Rafaëlle, Salvo, Eric, Richard, Isabelle, Béroud, Christophe, Christophe Béroud, Rafaëlle Bernard, Urtizberea, Jon Andoni, Labelle, Véronique, Bassez, Guillaume, Bevilacqua, Jorge A, Chapon, Françoise, Hammouda, El Hadi, Julien Bouvenot, Fernández, Carla, Laforêt, Pascal, Carla Fernandez, Pascal Laforêt, Pouget, Jean, Véronique Labelle, Lévy, Nicolas, Bouvenot, Julien, Leturcq, France, Martin Krahn, Eric Salvo   +47 more
core   +1 more source

Null variants in DYSF result in earlier symptom onset

, 2021
We investigated the clinical, laboratory, and genetic spectra in Korean patients with dysferlinopathy to clarify its genotype-phenotype correlation. We retrospectively reviewed 101 patients from 96 unrelated families with pathogenic variants of DYSF. The
최영철, 김승우, 홍지만, 김승민, 박형준, 신하영   +5 more
core   +1 more source

Gene Therapy for Allergic Diseases

, 2010
Allergic diseases, such as allergic asthma, allergic rhinitis, atopic dermatitis, conjunctivitis, urticaria, food allergy, and/or anaphylaxis, are associated with the skewing of immune responses towards a T helper 2 ( TH2) phenotype, resulting in ...
莊雅惠;楊曜旭;江伯倫, CHUANG, YA-HUI;YANG, YAO-HSU;CHIANG, BOR-LUEN   +1 more
core   +1 more source

A female case report of LGMD2B with compound heterozygous mutations of the DYSF gene and asymptomatic mutation of the X-linked DMD gene. [PDF]

Front Neurol, 2023
Cao X, Zeng L, Lu Z, Fan J, Tan S, Zhang M, Yin Z.   +6 more
europepmc   +1 more source