Results 41 to 50 of about 79,054 (352)

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Safinamide in Clinical Practice: A Spanish Multicenter Cohort Study

Brain Sciences, 2019
Background: Safinamide is an approved drug for the treatment of motor fluctuations of Parkinson’s Disease (PD) patients with a potential benefit on non-motor symptoms (NMS).
Gloria Martí-Andrés, Rayco Jiménez-Bolaños, José Matias Arbelo-González, Javier Pagonabarraga, Carmen Duran-Herrera, Rafael Valenti-Azcarate, Mª Rosario Luquin   +6 more
doaj   +1 more source

Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats

Frontiers in Immunology, 2021
Dyskinesia is a serious complication of Parkinson’s disease during levodopa (L-DOPA) treatment. The pathophysiology of L-DOPA-induced dyskinesia (LID) is complex and not fully illuminated. At present, treatment of dyskinesia is quite limited.
Chang-Qing Zheng, Hong-Xia Fan, Xiao-Xian Li, Jing-Jie Li, Shuo Sheng, Feng Zhang   +5 more
doaj   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Clinically important change on the Unified Dyskinesia Rating Scale among patients with Parkinson's disease experiencing dyskinesia

Frontiers in Neurology, 2022
BackgroundThe Unified Dyskinesia Rating Scale (UDysRS) evaluates dyskinesia in patients with Parkinson's disease (PD). A minimal clinically important change (MCIC)—the smallest change in a treatment outcome that a patient considers important—remains ...
Rajesh Pahwa, Susan Fox, Robert A. Hauser, Stuart Isaacson, Judy Lytle, Reed Johnson, Lily Llorens, Andrea E. Formella, Caroline M. Tanner   +8 more
doaj   +1 more source

Unraveling the interplay between dyskinesia and overactive bladder symptoms in Parkinson’s disease: a comprehensive cohort study based on the long-term follow-up database of Parkinson’s disease

BMC Neurology
Objectives Overactive bladder (OAB) and dyskinesia are frequent complications in patients with Parkinson’s disease (PD). However, the correlation between OAB and dyskinesia has been insufficiently explored.
Hong Jin, Yiheng Du, Jiahui Yan, Jinru Zhang, Xiaoyu Cheng, Chengjie Mao, Jing Chen, Chun-feng Liu   +7 more
doaj   +1 more source

Dyskinesia-hyperpyrexia syndrome in Parkinson's disease triggered by overdose of levodopa — a case report and literature review

Frontiers in Neurology
Dyskinesia-hyperpyrexia syndrome, a rare medical emergency in Parkinson's disease, is first described in 2010. It is characterized by severe continuous dyskinesia associated with rhabdomyolysis, hyperthermia and subsequent alteration of the mental state.
Xiangnan Du, Xuemei Wang, Xiaokun Geng, Xiaokun Geng   +3 more
doaj   +1 more source

Primary ciliary dyskinesia: mechanisms and management

The Application of Clinical Genetics, 2017
Primary ciliary dyskinesia is a genetically heterogeneous disorder of motile cilia that is predominantly inherited in an autosomal-recessive fashion.
N. Damseh, N. Quercia, Nisreen Rumman, S. Dell, R. Kim   +4 more
semanticscholar   +1 more source

Non‐Synaptic Function and Localization of Syntaxin‐Binding Protein 1 in a Mouse Model of STXBP1‐Related Epileptic Encephalopathy

Annals of Neurology, EarlyView.
Objective De novo mutations in the syntaxin‐binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders.
Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar1, Alexey I. Nesvizhskii, Michael D. Uhler, Jack M. Parent, Yu Wang   +7 more
wiley   +1 more source

Tardive dyskinesia

Geriatric Nursing, 1982
Tardive dyskinesia is now widely recognised as a neurological disorder associated with the administration of antipsychotic drugs. Prevalence is higher among the elderly. The cause is unknown but the hypothesis of hypersensitivity of post-synaptic dopamine receptors is currently generally accepted.
V A, Portnoi, J E, Johnson
openaire   +5 more sources