Results 111 to 120 of about 16,949 (278)

Polygenic determinants in extremes of high-density lipoprotein cholesterol

Journal of Lipid Research, 2017
HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect ...
Jacqueline S. Dron, Jian Wang, Cécile Low-Kam, Sumeet A. Khetarpal, John F. Robinson, Adam D. McIntyre, Matthew R. Ban, Henian Cao, David Rhainds, Marie-Pierre Dubé, Daniel J. Rader, Guillaume Lettre, Jean-Claude Tardif, Robert A. Hegele   +13 more
doaj   +1 more source

The Effect of Benralizumab and Mepolizumab on Use of Oral Glucocorticoids in Patients With Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective The phase 3 MANDARA study demonstrated noninferiority of benralizumab versus mepolizumab for remission in patients with eosinophilic granulomatosis with polyangiitis (EGPA). More benralizumab‐treated patients achieved complete withdrawal of oral glucocorticoids (OGCs).
Parameswaran K. Nair, Bernhard Hellmich, Arnaud Bourdin, David R. W. Jayne, Florence Roufosse, Nader Khalidi, Lena Börjesson Sjö, Ying Fan, Christopher McCrae, Sofia Necander, Eva Rodríguez‐Suárez, Anat Shavit, Claire Walton, Peter A. Merkel, Michael E. Wechsler   +14 more
wiley   +1 more source

Effect of adding bezafibrate to standard lipid-lowering therapy on post-fat load lipid levels in patients with familial dysbetalipoproteinemia. A randomized placebo-controlled crossover trial

Journal of Lipid Research, 2017
Familial dysbetalipoproteinemia (FD) is a genetic disorder associated with impaired postprandial lipid clearance. The effect of adding bezafibrate to standard lipid-lowering therapy on postprandial and fasting lipid levels in patients with FD is unknown.
Charlotte Koopal, A. David Marais, Jan Westerink, Yolanda van der Graaf, Frank L.J. Visseren   +4 more
doaj   +1 more source

Patient factors influencing the prescribing of lipid lowering drugs for primary prevention of cardiovascular disease in UK general practice: a national retrospective cohort study [PDF]

, 2013
BACKGROUND: Guidelines indicate eligibility for lipid lowering drugs, but it is not known to what extent GPs' follow guidelines in routine clinical practice or whether additional clinical factors systematically influence their prescribing decisions ...
Marshall, T., Mohammed, M.A., Wu, J., Yao, Guiqing Lily, Zhu, S.   +4 more
core   +2 more sources

Per‐ and Polyfluoroalkyl Substances and Hand Osteoarthritis: Data From the Osteoarthritis Initiative

Arthritis &Rheumatology, EarlyView.
Objective To explore whether biologic levels of specific per‐ and polyfluoroalkyl substances (PFAS) and a mixture of PFAS—reflecting the overall effect and accounting for correlations among PFAS—relate to incident hand osteoarthritis (HOA) and progression.
Jeffrey B. Driban, Lisa B. Rokoff, Bing Lu, Timothy E. McAlindon, Charles B. Eaton, Mary B. Roberts, Diana Mathes, Colleen Lestician, Zhijin Carrie Xu, Zhihua Tina Fan, Shawn P. O'Leary, Ida K. Haugen, Jérémie Sellam, Alice Courties, Abby F. Fleisch   +14 more
wiley   +1 more source

Endogenous versus exogenous fatty acid availability affects lysosomal acidity and MHC class II expression

Journal of Lipid Research, 2006
Although the immune system, inflammation, and cellular metabolism are linked to diseases associated with dyslipidemias, the mechanism(s) remain unclear.
S.C. Schweitzer, A.M. Reding, H.M. Patton, T.P. Sullivan, C.E. Stubbs, E. Villalobos-Menuey, S.A. Huber, M.K. Newell   +7 more
doaj   +1 more source

Beneficial effect of early initiation of lipid-lowering therapy following renal transplantation [PDF]

, 2017
Background. Renal transplant recipients have a significantly reduced life expectancy, largely due to premature cardiovascular disease. The aim of the current analysis was to investigate the importance of time of initiation of therapy after ...
Ambühl, Patrice, Cole, Edward, Fellström, Bengt, Gimpelewicz, Claudio, Grönhagen-Riska, Carola, Holdaas, Hallvard, Jardine, Alan G., Logan, John O., Madsen, Sören, Maes, Bart, Neumayer, Hans-Hellmut, Nyberg, Gudrun, Staffler, Beatrix   +12 more
core  

A Metabolomic Signature Predicts Gout Flare Clinical Outcome Associated With Colchicine Prophylaxis

Arthritis &Rheumatology, EarlyView.
Objective This study investigated that serum metabolomics, before urate‐lowering therapy (ULT) initiation, could serve as a biomarker for responsiveness to colchicine prophylaxis in patients with gout commencing treat‐to‐target ULT. Methods We studied a multicenter prospective cohort (n = 409) initiating treat‐to‐target ULT plus colchicine prophylaxis.
Wenyan Sun, Lingfang Xu, Haibing Chen, Mingshu Sun, Zhiqiang Li, Rui Li, Lidan Ma, Hui Zhang, Aichang Ji, Yuwei He, Na Wu, Le Yan, Robert Terkeltaub, Changgui Li   +13 more
wiley   +1 more source

Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake[S]

Journal of Lipid Research, 2019
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the LDL receptor (LDLR) for degradation, increasing plasma LDL and, consequently, cardiovascular risk.
Adri M. Galvan, John S. Chorba
doaj   +1 more source

Left Ventricular Outflow Tract Geometry as a Predictor of Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation Using the Evolut Series

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Predicting the need for permanent pacemaker implantation (PPM) after transcatheter aortic valve implantation (TAVI) is crucial for procedural planning and patient counseling. Aims To evaluate whether left ventricular outflow tract (LVOT) morphology, specifically a tapered configuration, predicts conduction disturbances requiring PPM
Mahmoud Abdelshafy, Angela McInerney, Ahmed Elmeanawy, Paolo Alberto Del Sole, Max Wagener, Hatem Helal, Mahmoud Abozaid, Ashraf Alamir, Tamer Fouad, Alsayed Almarghany, Briain MacNeill, Osama Soliman, Darren Mylotte, Mohammad Abdelghani   +13 more
wiley   +1 more source