Results 221 to 230 of about 23,715 (235)

Human dystrophin gene transfer: genetic correction of dystrophin deficiency

1993
Somatic gene therapy, as generally conceived, involves reconstituting a biological function by adding a normal gene to somatic, i.e. non-germline, cells which are genetically deficient in that gene product (Friedmann, 1989). Single gene or Mendelian disorders which are recessive (autosomal or X-linked) are particularly attractive candidates for such a ...
George Dickson, Matthew G. Dunckley
openaire   +3 more sources

Dystrophin is not essential for the integrity of the cytoskeleton

Acta Neuropathologica, 1994
Dystrophin is localized, in normal muscle fibers, on the cytoplasmic surface of the sarcolemma. The function of this protein is not known but, according to its structure and intracellular distribution, it seems likely that dystrophin interacts with other cytoskeletal proteins to form a complex linkage between myofibrils, sarcolemma and extracellular ...
MASSA, ROBERTO, Castellani, L, Silvestri, G, SANCESARIO, GIUSEPPE, BERNARDI, GIORGIO   +4 more
openaire   +5 more sources

Dystrophin and dystrophin-related protein expression in Torpedo marmorata electric organ

Neuroscience Letters, 1993
The presence of different dystrophin-related protein forms was investigated in electric organ as compared to cardiac, white or red skeletal muscles from Torpedo marmorata. Two strategies were followed. First, we used specific C-terminal dystrophin and dystrophin-related protein monoclonal antibodies which we characterized in the present study.
Jean J. Leger, Jocelyne Leger, E Fabbrizio, Dominique Mornet   +3 more
openaire   +3 more sources

Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix

Nature, 1992
The primary sequence of two components of the dystrophin-glycoprotein complex has been established by complementary, DNA cloning. The transmembrane 43K and extracellular 156K dystrophin-associated glycoproteins (DAGs) are encoded by a single messenger RNA and the extracellular 156K DAG binds laminin.
James M. Ervasti, Oxana Ibraghimov-Beskrovnaya, Cynthia J. Leveille, Suzanne W. Sernett, Kevin P. Campbell, Clive A. Slaughter   +5 more
openaire   +3 more sources

Dystrophin: A clinical perspective

Pediatric Neurology, 1990
Dystrophin, the protein product of the gene related to Duchenne and Becker muscular dystrophies, is a large cytoskeletal protein associated with the muscle fiber membrane. Recently identified dystrophin-related myopathies affecting animals can serve as experimental models for human disease.
openaire   +3 more sources

Dystrophin digest

Nature, 1989
K, Arahata, S, Ishiura, T, Tsukahara, H, Sugita   +3 more
openaire   +2 more sources

Hippocampal LTP in dystrophin- and dystrophin isoforms-deficient mice

1997
info:eu-repo/semantics ...
Godfraind, J M, Zizi, Martin, Deconinck, Nicolas   +2 more
openaire   +1 more source

Dystrophin and the Retina

Molecular Genetics and Metabolism, 1999
openaire   +2 more sources

Dystrophin and Dystrophin-Associated Proteins

2014
I. Kleyman, T.H. Brannagan
openaire   +1 more source

Dystrophin and Duchenne dystrophy

Neuromuscular Disorders, 2015
Victor Dubowitz, Ronald D. Cohn
openaire   +3 more sources