Results 231 to 240 of about 99,775 (288)

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial

open access: yesAllergy, EarlyView.
Both Full and Limited FESS result in clinically meaningful relief of disease‐specific HRQoL and nasal breathing, effectively improving nasal symptoms and sleep disturbance in CRSwNP patients. Clinically meaningful difference in decrease of SNOT‐22 scores between the groups was not found at 12‐ and 24–month follow‐up.
P. Virkkula   +10 more
wiley   +1 more source

Rademikibart for Asthma With Type 2 Biomarkers: Exploratory Subgroup Analyses From a Phase 2b Randomized Clinical Trial

open access: yesAllergy, EarlyView.
This study reports exploratory and predominantly post hoc subgroup analyses, according to baseline eosinophil count and FeNO levels. In adults with moderate‐to‐severe uncontrolled asthma, rademikibart produced rapid and sustained improvements in lung function and asthma control.
Michael E. Wechsler   +3 more
wiley   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

open access: yesAllergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz   +22 more
wiley   +1 more source

Single‐Cell Profiling Links T‐Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children

open access: yesAllergy, EarlyView.
Active EoE is associated with more and deeper epithelial eosinophil, mast cell, and T cell infiltration; inactive EoE resembles controls. During remission, PPI treatment leaves more tissue resident CD3+ T‐cells than TS. In active EoE, TH2 cells, IL‐10hi Tregs, and CD8+ cytotoxic T cells are enriched, while TH17 cells are relatively depleted.
Hannes Hoelz   +18 more
wiley   +1 more source

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