A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
Leaders in the global banking network: Analysis of the Bank for International Settlements network data. [PDF]
Bonato A, Palan JC, Szava A.
europepmc +1 more source
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng +7 more
wiley +1 more source
Retraction notice to "Is Islamic FinTech coherent with Islamic banking? A stakeholder's perspective during COVID-19" [Heliyon 8 (2022) e10485]. [PDF]
Karim S, Naeem MA, Abaji EE.
europepmc +1 more source
Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Behavioral Intruder Detection Based on Browsing Patterns with Automated Grouping of Requested Webpages. [PDF]
Wilczek A, Ciecierski K, Kamola M.
europepmc +1 more source
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
Digital wellbeing experience in the workplace: development and validation of the Work-Related Human Computer Interaction Questionnaire. [PDF]
Porcari DE +5 more
europepmc +1 more source
Trophic Diversity in Duckweed: Mixotrophy, More Than the Sum of its Extremes
In the context of rising DOC in aquatic environments, mixotrophic duckweed may impact carbon cycling by acting as either a carbon sink, as they absorb CO2 through photosynthesis, or a carbon source, as they release CO2 through respiration of absorbed DOC, which depends on DOC concentration, light availability, temperature, and other environmental ...
Zuoliang Sun +5 more
wiley +1 more source

