Results 121 to 130 of about 122,840 (288)

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Comparative assessment of respiratory, hematological and inflammatory profiles of long-term users of cigarettes, shisha, and e-cigarettes in Saudi Arabia

Tobacco Induced Diseases
Introduction Globally, over 1 billion people smoke, resulting in approximately 8 million deaths each year. Although the health risks associated with traditional cigarettes are extensively documented, there is an increasing need to evaluate the long-term ...
Mazen M. Homoud, Rowaida Qoutah, Gokul Krishna, Noran Harbli, Layan Saaty, Afrah Obaidan, Abdulrahman Alkhathami, Noran Jamil, Tala Μ. Alkayyat, Maryam Alsughayyir, Nada Gubari, Saleh Alkhathami, Ali Alqarni, Omar Alqurashi, Khalid Assiri, Khalid Saeed Alwadeai, Wafaa Abdulrahman, Husam Alahmadi, Ayedh Alahmari   +18 more
doaj   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

The global prevalence of E-cigarettes in youth: A comprehensive systematic review and meta-analysis

Public Health in Practice
Objectives: Smoking, especially cigarettes, is known as one of the most common social and health problems among people. E-cigarettes are another form of tobacco that has been an ordinary daily occurrence.Study Design: systematic review and meta-analysis.
Nader Salari, Sahel Rahimi, Niloofar Darvishi, Amir Abdolmaleki, Masoud Mohammadi   +4 more
doaj   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

Clinical Pharmacology &Therapeutics, EarlyView.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik, Ainhoa Gomez‐Lumbreras, Guilherme Del Fiol, Kensaku Kawamoto, Katy E. Trinkley, Thomas Reese, Aubrey Jones, Daniel C. Malone   +7 more
wiley   +1 more source

E-cigarettes in pregnancy: reducing or introducing harm? [PDF]

, 2016
Electronic cigarettes use has become increasingly prevalent with around 17.6% of population using these products. The serious harm to health caused by cigarette smoke is well publicised, and government advice has promoted the message that e-cigarettes ...
Weighall, Jaydene, Wilbraham, Susan
core   +1 more source

The role of DJ-1 in human primary alveolar type II cell injury induced by e-cigarette aerosol [PDF]

, 2019
Karim Bahmed, Chih-Ru Lin, Hannah Leah Tadeja Simborio, Loukmane Karim, Mark O. Aksoy, Steven G. Kelsen, Dhanendra Tomar, Muniswamy Madesh, John W. Elrod, Elise M. Messier, Robert J. Mason, Ellen M. Unterwald, Toby K. Eisenstein, Gerard J. Criner, Beata Kośmider   +14 more
openalex   +1 more source

Changing awareness and sources of tobacco and e-cigarettes among children in Great Britain [PDF]

, 2023
Jennie C Parnham, Charlotte Vrinten, Hazel Cheeseman, Laura Bunce, Nicholas S Hopkinson, Filippos T Filippidis, Anthony A Laverty   +6 more
openalex   +1 more source

Identification of Candidate Blood Biomarkers of Recombinant Human Erythropoietin Administration Using Targeted Polar Metabolomics by HILIC‐MS/MS

Drug Testing and Analysis, EarlyView.
Using targeted HILIC‐MS/MS metabolomics, inosine and hypoxanthine were identified as potential biomarkers of EPO administration. Their consistent and sensitive plasma responses highlight their promise for inclusion in the Athlete Biological Passport (ABP), warranting further investigation to enhance anti‐doping detection strategies. ABSTRACT Increasing
Olivier Salamin, Lejla Ramic, Raul Nicoli, Serge Rudaz, Davy Guillarme, Tiia Kuuranne   +5 more
wiley   +1 more source

E-Cigarettes: What Primary Care Providers Need to Know [PDF]

, 2016
E-cigarettes are gaining in popularity, yet our understanding of their health effects remains uncertain. Many people believe that they can aid in smoking cessation, however the evidence is inconclusive. The conflicting information in the public media has
Albert, Jennifer S
core   +1 more source