Results 121 to 130 of about 118,281 (298)

Analysis of interstitial lung disease in pharmacovigilance databases: Coding challenges and interpretation biases—An update

British Journal of Clinical Pharmacology, EarlyView.
Aim Clinically, interstitial lung disease (ILD) is a heterogeneous group of respiratory disorders. Due to their low incidence, pharmacovigilance database analysis is useful to detect them. Precise diagnosis is challenging as well as coding in these databases. Query criteria are among the key elements for a good signal detection.
Romane Freppel, Adeline Benis, Philippe Bonniaud, Jean‐Luc Faillie, Aurélie Grandvuillemin   +4 more
wiley   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Comparative assessment of respiratory, hematological and inflammatory profiles of long-term users of cigarettes, shisha, and e-cigarettes in Saudi Arabia

Tobacco Induced Diseases
Introduction Globally, over 1 billion people smoke, resulting in approximately 8 million deaths each year. Although the health risks associated with traditional cigarettes are extensively documented, there is an increasing need to evaluate the long-term ...
Mazen M. Homoud, Rowaida Qoutah, Gokul Krishna, Noran Harbli, Layan Saaty, Afrah Obaidan, Abdulrahman Alkhathami, Noran Jamil, Tala Μ. Alkayyat, Maryam Alsughayyir, Nada Gubari, Saleh Alkhathami, Ali Alqarni, Omar Alqurashi, Khalid Assiri, Khalid Saeed Alwadeai, Wafaa Abdulrahman, Husam Alahmadi, Ayedh Alahmari   +18 more
doaj   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

The global prevalence of E-cigarettes in youth: A comprehensive systematic review and meta-analysis

Public Health in Practice
Objectives: Smoking, especially cigarettes, is known as one of the most common social and health problems among people. E-cigarettes are another form of tobacco that has been an ordinary daily occurrence.Study Design: systematic review and meta-analysis.
Nader Salari, Sahel Rahimi, Niloofar Darvishi, Amir Abdolmaleki, Masoud Mohammadi   +4 more
doaj   +1 more source

Opinions and practices regarding electronic cigarette use among Romanian high school students

Gaceta Sanitaria, 2016
Objective: The study assessed awareness, opinions, practices regarding electronic cigarettes (e-cigarettes) and factors associated with their use among Romanian high school students.
Lucia Maria Lotrean, Bianca Varga, Monica Popa, Cornel Radu Loghin, Milena Adina Man, Antigona Trofor   +5 more
doaj   +1 more source

Perceptions of harm and addiction among dual users of cigarettes and e-cigarettes [PDF]

, 2016
Background: Tobacco harm perceptions are important factors in why individuals may initiate, substitute, and/or engage in dual or poly-tobacco use patterns.
Rozman, Julia S
core   +1 more source

Environmental Regulation at the Crossroads: A Review of Catalysts and Barriers in Circular Economy Transitions

Business Strategy and the Environment, EarlyView.
ABSTRACT Amid growing resource pressures, environmental regulation plays a critical role in enabling the transition to a circular economy (CE). This study conducts a systematic literature review to synthesize how different regulatory approaches—command‐and‐control, market‐based, voluntary, and reflexive—affect CE transitions across economic and ...
Li Yuan
wiley   +1 more source

Teacher–Student Relationship Quality as a Mediator in the Association of Parent–Child Communication With Adolescent Bullying Perpetration and Substance Use: Evidence From the 2017/2018 HBSC Study

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Bullying perpetration and substance use are two prevalent and concerning forms of delinquent behavior worldwide. Although parent–child communication has been theorized to reduce adolescents' involvement in these behaviors, empirical evidence remains mixed.
Hang Zhou, Ji‐Kang Chen
wiley   +1 more source

Awareness, current use of electronic cigarettes and associated smoking factors in Zhejiang Chinese adolescents.

PLoS ONE, 2019
OBJECTIVES:The present study aims at examining the prevalence of awareness and current use of electronic cigarettes (e-cigarettes) among middle and high school students from Zhejiang, China.
Meng Wang, Ru-Ying Hu, Jin Pan, Hao Wang, Min Yu, Kai-Xu Xie, Wei-Wei Gong   +6 more
doaj   +1 more source