Results 131 to 140 of about 32,634,218 (335)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Reflexivity of $L(E,\,F)$ [PDF]

open access: yesProceedings of the American Mathematical Society, 1972
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Reflexivity of L(E, F) [PDF]

open access: yesProceedings of the American Mathematical Society, 1973
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Arquitectura hidráulica en el noroeste argentino: monumentalidad y control del agua en el sur del Tawantinsuyu

open access: yesInvestigaciones y Ensayos, 2014
La arquitectura hidráulica Inca posee magistrales ejemplos de trabajo sobre pendientes rocosas, sobre todo para las zonas de los Andes Centrales.
Marco A. Giovannetti, Rodolfo A. Raffino
doaj  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

De patrones a empresarios. El campo argentino en la primera mitad del siglo XX

open access: yesInvestigaciones y Ensayos, 2014
Este trabajo de investigación histórica se propone caracterizar las estrategias - en tanto técnicas al servicio de un objetivo individual o colectivo, público o privado - elaboradas, implementadas y asumidas por quienes habiéndose transformado de ...
Noemí M. Girbal-Blacha
doaj  

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